SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation
Résumé
Development of SpiCee, a genetically encoded calcium scavenger d SpiCee inhibits calcium-dependent downstream pathways d SpiCee enables cell-specific manipulation of calcium-dependent processes in vivo d Subcellular targeting confers cell compartment specificity to SpiCee In Brief Ros et al. develop SpiCee, a genetically encoded calcium chelator that enables the manipulation of this second messenger in single cells with subcellular specificity. SpiCee alters the migration of developing cortical neurons in vivo. Targeting of lipid rafts prevents axonal repulsion, whereas exclusion from this subcellular compartment does not.
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