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Article Dans Une Revue Psychopharmacology Année : 2022

Peer presence and familiarity as key factors to reduce cocaine intake: an effect mediated by the Subthalamic Nucleus

Elodie Giorla
  • Fonction : Auteur
Sandra Nordmann
  • Fonction : Auteur
Cassandre Vielle
  • Fonction : Auteur
Yann Pelloux
P Roux
Camelia Protopopescu
Christine Manrique
  • Fonction : Auteur
Christian Montanari
  • Fonction : Auteur
Lisa Giorgi
  • Fonction : Auteur
Antoine Vilotitch
  • Fonction : Auteur
Pascal Huguet
Patrizia Carrieri
Christelle Baunez

Résumé

Rationale Stimulant use, including cocaine, often occurs in a social context whose influence is important to understand to decrease intake and reduce associated harms. Although the importance of social influence in the context of drug addiction is known, there is a need for studies assessing its neurobiological substrate and for translational research. Objectives Here, we explored the influence of peer presence and familiarity on cocaine intake and its neurobiological basis. Given the regulatory role of the subthalamic nucleus (STN) on cocaine intake and emotions, we investigated its role on such influence of social context on cocaine intake. Methods We first compared cocaine consumption in various conditions (with no peer present or with peers with different characteristics: abstinent peer or drug-taking peer, familiar or not, cocaine-naive or not, dominant or subordinate) in rats (n = 90). Then, with a translational approach, we assessed the influence of the social context (alone, in the group, in a dyad with familiar or non-familiar peers) on drug intake in human drug users (n = 77). Results The drug consumption was reduced when a peer was present, abstinent, or drug-taking as well, and further dimin- ished when the peer was non-familiar. The presence of a non-familiar and drug-naive peer represents key conditions to diminish cocaine intake. The STN lesion by itself reduced cocaine intake to the level reached in presence of a non-familiar naive peer and affected social cognition, positioning the STN as one neurobiological substrate of social influence on drug intake. Then, the human study confirmed the beneficial effect of social presence, especially of non-familiar peers. Conclusion Our results indirectly support the use of social interventions and harm reduction strategies and position the STN as a key cerebral structure to mediate these effects.
The presence of a non-familiar and possibly drug-naive peer is the most efficient condition to diminish stimulant intake. Our results indirectly support the use of harm reduction strategies, in particular supervised consumption rooms for stimulant users.
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Dates et versions

hal-02990844 , version 1 (10-11-2020)

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Elodie Giorla, Sandra Nordmann, Cassandre Vielle, Yann Pelloux, P Roux, et al.. Peer presence and familiarity as key factors to reduce cocaine intake: an effect mediated by the Subthalamic Nucleus. Psychopharmacology, inPress, ⟨10.1007/s00213-021-06033-0⟩. ⟨hal-02990844⟩
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