<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02989234</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-15T03:26:12+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis</title>
            <author role="aut">
              <persName>
                <forename type="first">Benjamin</forename>
                <surname>Vitre</surname>
              </persName>
              <email type="md5">8e7815b66288a6ba6a5e26123994c280</email>
              <email type="domain">crbm.cnrs.fr</email>
              <idno type="idhal" notation="string">benjamin-vitre</idno>
              <idno type="idhal" notation="numeric">738464</idno>
              <idno type="halauthorid" notation="string">6659-738464</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5954-4270</idno>
              <idno type="IDREF">https://www.idref.fr/130631531</idno>
              <affiliation ref="#struct-1087101"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Taulet</surname>
              </persName>
              <idno type="halauthorid">264918-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Guesdon</surname>
              </persName>
              <idno type="halauthorid">470847-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Audrey</forename>
                <surname>Douanier</surname>
              </persName>
              <idno type="halauthorid">1423167-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aurelie</forename>
                <surname>Dosdane</surname>
              </persName>
              <idno type="halauthorid">2058227-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Melanie</forename>
                <surname>Cisneros</surname>
              </persName>
              <idno type="halauthorid">2058228-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Justine</forename>
                <surname>Maurin</surname>
              </persName>
              <idno type="halauthorid">1421583-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Sabrina</forename>
                <surname>Hettinger</surname>
              </persName>
              <idno type="halauthorid">1692381-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christelle</forename>
                <surname>Anguille</surname>
              </persName>
              <idno type="halauthorid">369573-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michael</forename>
                <surname>Taschner</surname>
              </persName>
              <idno type="halauthorid">1018327-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Esben</forename>
                <surname>Lorentzen</surname>
              </persName>
              <idno type="halauthorid">223627-0</idno>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Benedicte</forename>
                <surname>Delaval</surname>
              </persName>
              <email type="md5">b217e9c748bc62feae62580b2bd03e25</email>
              <email type="domain">crbm.cnrs.fr</email>
              <idno type="idhal" notation="string">benedicte-delaval</idno>
              <idno type="idhal" notation="numeric">740070</idno>
              <idno type="halauthorid" notation="string">41466-740070</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0274-185X</idno>
              <idno type="IDREF">https://www.idref.fr/095046690</idno>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Benjamin</forename>
                <surname>Vitre</surname>
              </persName>
              <email type="md5">8e7815b66288a6ba6a5e26123994c280</email>
              <email type="domain">crbm.cnrs.fr</email>
            </editor>
            <funder ref="#projanr-48098"/>
            <funder ref="#projanr-35517"/>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-11-25 10:23:50</date>
              <date type="whenModified">2024-04-17 15:30:07</date>
              <date type="whenReleased">2020-11-25 10:27:37</date>
              <date type="whenProduced">2020-06-04</date>
              <date type="whenEndEmbargoed">2020-11-25</date>
              <ref type="file" target="https://hal.science/hal-02989234v1/document">
                <date notBefore="2020-11-25"/>
              </ref>
              <ref type="file" subtype="publisherPaid" n="1" target="https://hal.science/hal-02989234v1/file/D708C4C0-6DE3-4EDD-9634-DC06F00F9967.pdf" id="file-3023059-2662585">
                <date notBefore="2020-11-25"/>
              </ref>
              <ref type="externalLink" target="https://doi.org/10.15252/embr.201949234"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="459504">
                <persName>
                  <forename>Benjamin</forename>
                  <surname>Vitre</surname>
                </persName>
                <email type="md5">8e7815b66288a6ba6a5e26123994c280</email>
                <email type="domain">crbm.cnrs.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02989234</idno>
            <idno type="halUri">https://hal.science/hal-02989234</idno>
            <idno type="halBibtex">vitre:hal-02989234</idno>
            <idno type="halRefHtml">&lt;i&gt;EMBO Reports&lt;/i&gt;, 2020, 21 (6), &lt;a target="_blank" href="https://dx.doi.org/10.15252/embr.201949234"&gt;&amp;#x27E8;10.15252/embr.201949234&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">EMBO Reports, 2020, 21 (6), &amp;#x27E8;10.15252/embr.201949234&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-3023059-2662585"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="CRBM">Centre de recherches de biochimie macromoléculaire</idno>
            <idno type="stamp" n="BS">Biologie-Santé</idno>
            <idno type="stamp" n="UNIV-MONTPELLIER">Université de Montpellier</idno>
            <idno type="stamp" n="ANR">ANR</idno>
            <idno type="stamp" n="UM-2015-2021" corresp="UNIV-MONTPELLIER">Université de Montpellier (2015-2021)</idno>
            <idno type="stamp" n="FRM">Fondation pour la Recherche Médicale</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Benjamin</forename>
                    <surname>Vitre</surname>
                  </persName>
                  <email type="md5">8e7815b66288a6ba6a5e26123994c280</email>
                  <email type="domain">crbm.cnrs.fr</email>
                  <idno type="idhal" notation="string">benjamin-vitre</idno>
                  <idno type="idhal" notation="numeric">738464</idno>
                  <idno type="halauthorid" notation="string">6659-738464</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5954-4270</idno>
                  <idno type="IDREF">https://www.idref.fr/130631531</idno>
                  <affiliation ref="#struct-1087101"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Taulet</surname>
                  </persName>
                  <idno type="halauthorid">264918-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Guesdon</surname>
                  </persName>
                  <idno type="halauthorid">470847-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Audrey</forename>
                    <surname>Douanier</surname>
                  </persName>
                  <idno type="halauthorid">1423167-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aurelie</forename>
                    <surname>Dosdane</surname>
                  </persName>
                  <idno type="halauthorid">2058227-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Melanie</forename>
                    <surname>Cisneros</surname>
                  </persName>
                  <idno type="halauthorid">2058228-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Justine</forename>
                    <surname>Maurin</surname>
                  </persName>
                  <idno type="halauthorid">1421583-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Sabrina</forename>
                    <surname>Hettinger</surname>
                  </persName>
                  <idno type="halauthorid">1692381-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christelle</forename>
                    <surname>Anguille</surname>
                  </persName>
                  <idno type="halauthorid">369573-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michael</forename>
                    <surname>Taschner</surname>
                  </persName>
                  <idno type="halauthorid">1018327-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Esben</forename>
                    <surname>Lorentzen</surname>
                  </persName>
                  <idno type="halauthorid">223627-0</idno>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Benedicte</forename>
                    <surname>Delaval</surname>
                  </persName>
                  <email type="md5">b217e9c748bc62feae62580b2bd03e25</email>
                  <email type="domain">crbm.cnrs.fr</email>
                  <idno type="idhal" notation="string">benedicte-delaval</idno>
                  <idno type="idhal" notation="numeric">740070</idno>
                  <idno type="halauthorid" notation="string">41466-740070</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0274-185X</idno>
                  <idno type="IDREF">https://www.idref.fr/095046690</idno>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">12850</idno>
                <idno type="issn">1469-221X</idno>
                <idno type="eissn">1469-3178</idno>
                <title level="j">EMBO Reports</title>
                <imprint>
                  <publisher>EMBO Press</publisher>
                  <biblScope unit="volume">21</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <date type="datePub">2020-06-04</date>
                </imprint>
              </monogr>
              <idno type="doi">10.15252/embr.201949234</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Cell Cycle</term>
                <term xml:lang="en">Polarity &amp; Cytoskeleton</term>
                <term xml:lang="en">mitosis Subject Categories Cell Adhesion</term>
                <term xml:lang="en">IFT proteins</term>
                <term xml:lang="en">HSET/KifC1</term>
                <term xml:lang="en">centrosome clustering</term>
                <term xml:lang="en">cancer</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Centrosome amplification is a hallmark of cancer, and centrosome clustering is essential for cancer cell survival. The mitotic kinesin HSET is an essential contributor to this process. Recent studies have highlighted novel functions for intraflagellar transport (IFT) proteins in regulating motors and mitotic processes. Here, using siRNA knock-down of various IFT proteins or AID-inducible degradation of endogenous IFT88 in combination with small-molecule inhibition of HSET, we show that IFT proteins together with HSET are required for efficient centrosome clustering. We identify a direct interaction between the kinesin HSET and IFT proteins, and we define how IFT proteins contribute to clustering dynamics during mitosis using high-resolution live imaging of centrosomes. Finally, we demonstrate the requirement of IFT88 for efficient centrosome clustering in a variety of cancer cell lines naturally harboring supernumerary centrosomes and its importance for cancer cell proliferation. Overall, our data unravel a novel role for the IFT machinery in centrosome clustering during mitosis in cells harboring supernumerary centrosomes.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1087101" status="OLD">
          <idno type="ISNI">000000040598968X</idno>
          <idno type="RNSR">200711904N</idno>
          <idno type="ROR">https://ror.org/01xpc6869</idno>
          <orgName>Centre de recherche en Biologie cellulaire de Montpellier</orgName>
          <orgName type="acronym">CRBM</orgName>
          <date type="start">2015-01-01</date>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>1919 Route de Mende 34293 MONTPELLIER CEDEX 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.crbm.cnrs.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-410122" type="direct"/>
            <relation name="UMR5237" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-410122" status="OLD">
          <idno type="ISNI">0000000120970141</idno>
          <idno type="ROR">https://ror.org/051escj72</idno>
          <orgName>Université de Montpellier</orgName>
          <orgName type="acronym">UM</orgName>
          <date type="end">2021-12-31</date>
          <desc>
            <address>
              <addrLine>163 rue Auguste Broussonnet - 34090 Montpellier</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.umontpellier.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
      <listOrg type="projects">
        <org type="anrProject" xml:id="projanr-48098" status="VALID">
          <idno type="anr">ANR-18-CE11-0025</idno>
          <idno type="program">APPEL À PROJETS GÉNÉRIQUE 2018</idno>
          <orgName>IRMM</orgName>
          <desc>Caractérisation, in vitro, de la régulation des moteurs moléculaires et de l'organisation des microtubules par les protéines du transport Intra-flagellaire.</desc>
          <date type="start">2018</date>
        </org>
        <org type="anrProject" xml:id="projanr-35517" status="VALID">
          <idno type="anr">ANR-12-CHEX-0005</idno>
          <idno type="program">Chaires d’excellence</idno>
          <orgName>CilMitoCyst</orgName>
          <desc>Etude du rôle des protéines du cil primaire lors de la division cellulaire : implications dans la formation de kystes reinaux et les ciliopathies.</desc>
          <date type="start">2012</date>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>