<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02985525</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-25T21:39:23+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report</title>
            <author role="aut">
              <persName>
                <forename type="first">Karim</forename>
                <surname>Arafah</surname>
              </persName>
              <idno type="halauthorid">1116660-0</idno>
              <affiliation ref="#struct-562314"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Fabrice</forename>
                <surname>Lopez</surname>
              </persName>
              <email type="md5">50eab87c360338e52a6dd50b08a72ed3</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">fabrice-lopez</idno>
              <idno type="idhal" notation="numeric">15819</idno>
              <idno type="halauthorid" notation="string">37596-15819</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2401-0292</idno>
              <affiliation ref="#struct-526050"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Caroline</forename>
                <surname>Cazin</surname>
              </persName>
              <idno type="halauthorid">1677493-0</idno>
              <affiliation ref="#struct-1043222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Zine‐eddine</forename>
                <surname>Kherraf</surname>
              </persName>
              <idno type="halauthorid">1425214-0</idno>
              <affiliation ref="#struct-1043222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Virginie</forename>
                <surname>Tassistro</surname>
              </persName>
              <email type="md5">6d002a05112364637f5b64de61d9c6a2</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="string">virginie-tassistro</idno>
              <idno type="idhal" notation="numeric">173584</idno>
              <idno type="halauthorid" notation="string">25314-173584</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4183-8339</idno>
              <idno type="IDREF">https://www.idref.fr/123705088</idno>
              <affiliation ref="#struct-188653"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anderson</forename>
                <surname>Loundou</surname>
              </persName>
              <email type="md5">87cb8929feb110929c98fca8ed73d458</email>
              <email type="domain">univ-amu.fr</email>
              <idno type="idhal" notation="numeric">942868</idno>
              <idno type="halauthorid" notation="string">370593-942868</idno>
              <affiliation ref="#struct-198056"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christophe</forename>
                <surname>Arnoult</surname>
              </persName>
              <email type="md5">0024109dfd9549c951b195db6093b13b</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">christophe-arnoult</idno>
              <idno type="idhal" notation="numeric">178224</idno>
              <idno type="halauthorid" notation="string">20959-178224</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3753-5901</idno>
              <idno type="IDREF">https://www.idref.fr/097411833</idno>
              <affiliation ref="#struct-1043222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Nicolas</forename>
                <surname>Thierry-Mieg</surname>
              </persName>
              <email type="md5">c1694ce703d95a9106b012699c901e7c</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">nthierry</idno>
              <idno type="idhal" notation="numeric">740294</idno>
              <idno type="halauthorid" notation="string">41506-740294</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6007-2014</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7667-2853</idno>
              <idno type="IDREF">https://www.idref.fr/060569638</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6007-2014</idno>
              <affiliation ref="#struct-1043051"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Philippe</forename>
                <surname>Bulet</surname>
              </persName>
              <email type="md5">6e8b33dbdb4816a45bc68a232f851d79</email>
              <email type="domain">univ-grenoble-alpes.fr</email>
              <idno type="idhal" notation="string">philippe-bulet</idno>
              <idno type="idhal" notation="numeric">180758</idno>
              <idno type="halauthorid" notation="string">4700-180758</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9016-265X</idno>
              <idno type="IDREF">https://www.idref.fr/128857250</idno>
              <affiliation ref="#struct-562314"/>
              <affiliation ref="#struct-1043222"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Roberte</forename>
                <surname>Guichaoua</surname>
              </persName>
              <idno type="halauthorid">1116661-0</idno>
              <affiliation ref="#struct-188653"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Pierre F</forename>
                <surname>Ray</surname>
              </persName>
              <idno type="halauthorid">658830-0</idno>
              <affiliation ref="#struct-1043222"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Virginie</forename>
                <surname>TASSISTRO</surname>
              </persName>
              <email type="md5">6d002a05112364637f5b64de61d9c6a2</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2021-02-15 12:11:49</date>
              <date type="whenModified">2026-04-02 15:54:04</date>
              <date type="whenReleased">2021-02-15 12:58:39</date>
              <date type="whenProduced">2021</date>
              <date type="whenEndEmbargoed">2021-06-18</date>
              <ref type="file" target="https://hal.science/hal-02985525v1/document">
                <date notBefore="2021-06-18"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02985525v1/file/Arafah%202020.pdf" id="file-3141503-2753409">
                <date notBefore="2021-06-18"/>
              </ref>
              <ref type="externalLink" target="https://hal.archives-ouvertes.fr/hal-02985525/file/Arafah%202020.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="621275">
                <persName>
                  <forename>Virginie</forename>
                  <surname>TASSISTRO</surname>
                </persName>
                <email type="md5">6d002a05112364637f5b64de61d9c6a2</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02985525</idno>
            <idno type="halUri">https://hal.science/hal-02985525</idno>
            <idno type="halBibtex">arafah:hal-02985525</idno>
            <idno type="halRefHtml">&lt;i&gt;Human Reproduction&lt;/i&gt;, 2021, 36 (3), pp.693-701. &lt;a target="_blank" href="https://dx.doi.org/10.1093/humrep/deaa329"&gt;&amp;#x27E8;10.1093/humrep/deaa329&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Human Reproduction, 2021, 36 (3), pp.693-701. &amp;#x27E8;10.1093/humrep/deaa329&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://hal.science/licences/copyright/">Copyright - All rights reserved<ref corresp="#file-3141503-2753409"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="IRD">IRD - Institut de recherche pour le développement</idno>
            <idno type="stamp" n="UNIV-AVIGNON">Université d'Avignon</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
            <idno type="stamp" n="IMAG">IMAG</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="INPG">Institut polytechnique de Grenoble</idno>
            <idno type="stamp" n="IMBE" corresp="OSU-INSTITUT-PYTHEAS">Institut méditerranéen de biodiversité et d'écologie marine et continentale</idno>
            <idno type="stamp" n="OSU-INSTITUT-PYTHEAS">OSU INSTITUT PYTHEAS</idno>
            <idno type="stamp" n="TIMC-IMAG">TIMC</idno>
            <idno type="stamp" n="TAGC">Technologies avancées pour le génôme et la clinique</idno>
            <idno type="stamp" n="UNIV-LYON">Université de Lyon</idno>
            <idno type="stamp" n="IMBE-SERVICES-COMMUNS" corresp="IMBE">IMBE - Services communs</idno>
            <idno type="stamp" n="UGA-EPE">Université Grenoble Alpes [2020-*]</idno>
            <idno type="stamp" n="TEST3-HALCNRS">TEST3-HALCNRS</idno>
            <idno type="stamp" n="TEST4-HALCNRS">collection test</idno>
            <idno type="stamp" n="TIMC-MAGE" corresp="TIMC-IMAG">MAGe :  Modèles et Algorithmes pour la Génomique </idno>
            <idno type="stamp" n="TEST5-HALCNRS">collection test 5</idno>
            <idno type="stamp" n="INEE-CNRS">Institut écologie et environnement du CNRS</idno>
            <idno type="stamp" n="IMBE-SANTES" corresp="IMBE">IMBE-SANTES</idno>
            <idno type="stamp" n="IAB_GRENOBLE">IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)</idno>
            <idno type="stamp" n="TEST-UGA">TEST-UGA</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Defect in the nuclear pore membrane glycoprotein 210-like gene is associated with extreme uncondensed sperm nuclear chromatin and male infertility: a case report</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Karim</forename>
                    <surname>Arafah</surname>
                  </persName>
                  <idno type="halauthorid">1116660-0</idno>
                  <affiliation ref="#struct-562314"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Fabrice</forename>
                    <surname>Lopez</surname>
                  </persName>
                  <email type="md5">50eab87c360338e52a6dd50b08a72ed3</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">fabrice-lopez</idno>
                  <idno type="idhal" notation="numeric">15819</idno>
                  <idno type="halauthorid" notation="string">37596-15819</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2401-0292</idno>
                  <affiliation ref="#struct-526050"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Caroline</forename>
                    <surname>Cazin</surname>
                  </persName>
                  <idno type="halauthorid">1677493-0</idno>
                  <affiliation ref="#struct-1043222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Zine‐eddine</forename>
                    <surname>Kherraf</surname>
                  </persName>
                  <idno type="halauthorid">1425214-0</idno>
                  <affiliation ref="#struct-1043222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Virginie</forename>
                    <surname>Tassistro</surname>
                  </persName>
                  <email type="md5">6d002a05112364637f5b64de61d9c6a2</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="string">virginie-tassistro</idno>
                  <idno type="idhal" notation="numeric">173584</idno>
                  <idno type="halauthorid" notation="string">25314-173584</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4183-8339</idno>
                  <idno type="IDREF">https://www.idref.fr/123705088</idno>
                  <affiliation ref="#struct-188653"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anderson</forename>
                    <surname>Loundou</surname>
                  </persName>
                  <email type="md5">87cb8929feb110929c98fca8ed73d458</email>
                  <email type="domain">univ-amu.fr</email>
                  <idno type="idhal" notation="numeric">942868</idno>
                  <idno type="halauthorid" notation="string">370593-942868</idno>
                  <affiliation ref="#struct-198056"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christophe</forename>
                    <surname>Arnoult</surname>
                  </persName>
                  <email type="md5">0024109dfd9549c951b195db6093b13b</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">christophe-arnoult</idno>
                  <idno type="idhal" notation="numeric">178224</idno>
                  <idno type="halauthorid" notation="string">20959-178224</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3753-5901</idno>
                  <idno type="IDREF">https://www.idref.fr/097411833</idno>
                  <affiliation ref="#struct-1043222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Nicolas</forename>
                    <surname>Thierry-Mieg</surname>
                  </persName>
                  <email type="md5">c1694ce703d95a9106b012699c901e7c</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">nthierry</idno>
                  <idno type="idhal" notation="numeric">740294</idno>
                  <idno type="halauthorid" notation="string">41506-740294</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/M-6007-2014</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7667-2853</idno>
                  <idno type="IDREF">https://www.idref.fr/060569638</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/M-6007-2014</idno>
                  <affiliation ref="#struct-1043051"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Philippe</forename>
                    <surname>Bulet</surname>
                  </persName>
                  <email type="md5">6e8b33dbdb4816a45bc68a232f851d79</email>
                  <email type="domain">univ-grenoble-alpes.fr</email>
                  <idno type="idhal" notation="string">philippe-bulet</idno>
                  <idno type="idhal" notation="numeric">180758</idno>
                  <idno type="halauthorid" notation="string">4700-180758</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9016-265X</idno>
                  <idno type="IDREF">https://www.idref.fr/128857250</idno>
                  <affiliation ref="#struct-562314"/>
                  <affiliation ref="#struct-1043222"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Roberte</forename>
                    <surname>Guichaoua</surname>
                  </persName>
                  <idno type="halauthorid">1116661-0</idno>
                  <affiliation ref="#struct-188653"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Pierre F</forename>
                    <surname>Ray</surname>
                  </persName>
                  <idno type="halauthorid">658830-0</idno>
                  <affiliation ref="#struct-1043222"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13965</idno>
                <idno type="issn">0268-1161</idno>
                <idno type="eissn">1460-2350</idno>
                <title level="j">Human Reproduction</title>
                <imprint>
                  <publisher>Oxford University Press (OUP)</publisher>
                  <biblScope unit="volume">36</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">693-701</biblScope>
                  <date type="datePub">2021</date>
                  <date type="dateEpub">2020-12-18</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1093/humrep/deaa329</idno>
              <idno type="pubmed">33332558</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Proteomics</term>
                <term xml:lang="en">Exome sequencing</term>
                <term xml:lang="en">NUP210L</term>
                <term xml:lang="en">Spermatogenesis</term>
                <term xml:lang="en">Chromatin remodeling</term>
                <term xml:lang="en">Uncondensed sperm nucleus</term>
                <term xml:lang="en">Male infertility</term>
              </keywords>
              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Chromatin</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Infertility</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Membrane Glycoproteins</classCode>
              <classCode scheme="mesh">Mice</classCode>
              <classCode scheme="mesh">Nuclear Pore</classCode>
              <classCode scheme="mesh">Spermatogenesis</classCode>
              <classCode scheme="mesh">Spermatozoa</classCode>
              <classCode scheme="halDomain" n="sdv.bdd.gam">Life Sciences [q-bio]/Development Biology/Gametogenesis</classCode>
              <classCode scheme="halDomain" n="sdv.bdlr.rs">Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>After the two meiotic divisions, haploid round spermatids undergo dramatic changes to become mature spermatozoa. One of the main transformations consists of compacting the cell nucleus to confer the sperm its remarkable hydrodynamic property and to protect its DNA from the oxidative stress it will encounter during its reproductivejourney.Here, we studied an infertile subject with low sperm count, poor motility and highly abnormal spermatozoa with strikingly large heads due to highly uncondensed nuclear sperm DNA. Whole exome sequencing was performed on the subject’s DNA to identify the genetic defect responsible for this severe sperm anomaly.Bioinformatics analysis of exome sequence data uncovered a single candidate variant: a homozygous loss of function variant, ENST00000368559.7:c.718-1G&gt;A, altering a consensus splice site expected to prevent the synthesis of the NUP210L protein. High-resolution mass spectrometry of sperm protein extracts did not reveal any NUP210L peptide sequence in the patient’s sperm, contrary to what was observed in control donors, thus confirming the absence of NUP210L in the patient’s sperm.Interestingly, homozygous Nup210l knock-out mice have been shown to be infertile due to a reduced sperm count, a high proportion of round-headed sperm, other head and flagella defects and a poor motility.NUP210L is almost exclusively expressed in the testis and sequence analogy suggests that it encodes a nuclear pore membrane glycoprotein. The protein might be crucial to regulate nuclear trafficking during and/or before spermiogenesis, its absencepotentially impeding adequate nuclear compaction by preventing the entry of histone variants/transition proteins/protamines into the nucleus and/or by preventing the adequate replacement of core histones.This work describes a new gene necessary for male fertility, potentially improving the efficiency of the genetic diagnosis of male infertility.The function of NUP210L still remains to be resolved and its future investigation will help to understand the complex mechanisms necessary for sperm compaction.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-562314" status="INCOMING">
          <orgName>Plateforme Biopark d'Archamps</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-526050" status="VALID">
          <idno type="RNSR">201220169A</idno>
          <orgName>Theories and Approaches of Genomic Complexity</orgName>
          <orgName type="acronym">TAGC</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://tagc.univ-amu.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-198056" type="direct"/>
            <relation name="U1090" active="#struct-303623" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-1043222" status="VALID">
          <idno type="IdRef">200912658</idno>
          <idno type="RNSR">201622378J</idno>
          <idno type="ROR">https://ror.org/05kwbf598</idno>
          <orgName>Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)</orgName>
          <orgName type="acronym">IAB</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Institut pour l'Avancée des BiosciencesCentre de Recherche UGA / Inserm U 1209 / CNRS UMR 5309Site Santé - Allée des Alpes 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://iab-grenoble.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-200221" type="direct"/>
            <relation active="#struct-199980" type="indirect"/>
            <relation active="#struct-257328" type="direct"/>
            <relation name="U1209" active="#struct-303623" type="direct"/>
            <relation name="UMR5309" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-188653" status="VALID">
          <idno type="IdRef">179775251</idno>
          <idno type="ISNI">0000000406002381</idno>
          <idno type="RNSR">201220339K</idno>
          <idno type="ROR">https://ror.org/0409c3995</idno>
          <orgName>Institut méditerranéen de biodiversité et d'écologie marine et continentale</orgName>
          <orgName type="acronym">IMBE</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix Marseille Université, Campus Etoile, Faculté St-Jérôme case 421 Av. . escadrille Normandie-Niemen 13397 MARSEILLE CEDEX 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.imbe.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR7263" active="#struct-195507" type="direct"/>
            <relation name="UMR7263" active="#struct-198056" type="direct"/>
            <relation name="UMR7263" active="#struct-302715" type="direct"/>
            <relation name="UMR7263" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-198056" status="VALID">
          <idno type="IdRef">15863621X</idno>
          <idno type="ISNI">0000 0001 2176 4817</idno>
          <idno type="ROR">https://ror.org/035xkbk20</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-1043051" status="VALID">
          <orgName>Biologie Computationnelle et Modélisation</orgName>
          <orgName type="acronym">TIMC-BCM</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Pavillon Taillefer, Rond-point de la Croix de Vie, 38700 La Tronche</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/bcm</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1043049" type="direct"/>
            <relation active="#struct-301767" type="indirect"/>
            <relation name="UMR5525" active="#struct-441569" type="indirect"/>
            <relation active="#struct-1042703" type="indirect"/>
            <relation active="#struct-1043329" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-200221" status="VALID">
          <orgName>Établissement Français du Sang Auvergne-Rhône-Alpes [Lyon]</orgName>
          <orgName type="acronym">EFS Auvergne-Rhône-Alpes - Lyon</orgName>
          <desc>
            <address>
              <addrLine>Site de Lyon. 3 Rue du Vercors 69364 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.efs.sante.fr/lefs-en-auvergne-rhone-alpes</ref>
          </desc>
          <listRelation>
            <relation active="#struct-199980" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-199980" status="VALID">
          <orgName>Établissement Français du Sang [La Plaine Saint-Denis]</orgName>
          <orgName type="acronym">EFS</orgName>
          <date type="start">2000-01-01</date>
          <desc>
            <address>
              <addrLine>20 Avenue du Stade de France 93218 La Plaine Saint Denis</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.dondusang.net</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-257328" status="VALID">
          <idno type="IdRef">034137076</idno>
          <idno type="ROR">https://ror.org/041rhpw39</idno>
          <orgName>CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble</orgName>
          <orgName type="acronym">CHUGA</orgName>
          <desc>
            <address>
              <addrLine>CS 1021738043 Grenoble cedex 9</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.chu-grenoble.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-1042703" status="VALID">
          <idno type="IdRef">240648315</idno>
          <idno type="ROR">https://ror.org/02rx3b187</idno>
          <orgName>Université Grenoble Alpes</orgName>
          <orgName type="acronym">UGA</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>Adresse CS 40700 - 38058 Grenoble cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-grenoble-alpes.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-195507" status="VALID">
          <idno type="ROR">https://ror.org/00mfpxb84</idno>
          <orgName>Avignon Université</orgName>
          <orgName type="acronym">AU</orgName>
          <desc>
            <address>
              <addrLine>74 rue Louis Pasteur - 84 029 Avignon cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-avignon.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-302715" status="VALID">
          <orgName>Institut de recherche pour le développement [IRD] : UMR237</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-1043049" status="VALID">
          <idno type="IdRef">14728936X</idno>
          <idno type="ISNI">0000 0004 4687 1979</idno>
          <idno type="RNSR">199511969L</idno>
          <idno type="ROR">https://ror.org/03985kf35</idno>
          <orgName>Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525</orgName>
          <orgName type="acronym">TIMC</orgName>
          <date type="start">2021-01-01</date>
          <desc>
            <address>
              <addrLine>Domaine de la Merci, 38706 La Tronche, France</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.timc.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-301767" type="direct"/>
            <relation name="UMR5525" active="#struct-441569" type="direct"/>
            <relation active="#struct-1042703" type="direct"/>
            <relation active="#struct-1043329" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-301767" status="VALID">
          <idno type="ROR">https://ror.org/01c7wz417</idno>
          <orgName>VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement</orgName>
          <orgName type="acronym">VAS</orgName>
          <date type="start">2010-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lyon, VetAgro Sup, 69280 Marcy l'Etoile (campus vétérinaire); Université de Clermont, VetAgro Sup, 63370 Lempdes (campus agronomique)</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.vetagro-sup.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-1043329" status="VALID">
          <idno type="IdRef">026388804</idno>
          <idno type="ROR">https://ror.org/05sbt2524</idno>
          <orgName>Institut polytechnique de Grenoble - Grenoble Institute of Technology</orgName>
          <orgName type="acronym">Grenoble INP</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>46 avenue Félix Viallet 38031 Grenoble Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.grenoble-inp.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-1042703" type="direct"/>
          </listRelation>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>