Article Dans Une Revue ChemBioChem Année : 2021

Artificial enzymes for Diels‐Alder reactions

Résumé

Diels-Alder (DA) reaction is a cycloaddition of a conjugated diene and an alkene (dienophile) leading to the formation of a cyclohexene derivative via a concerted mechanism. As DA reaction generally proceeds with a high degree of regio-and stereoselectivity, it is widely used in synthetic organic chemistry. Considering eco-conscious public and governmental movements, efforts are directed towards the development of industrial processes that meet environmental concerns. Artificial enzymes, that can be developed to catalyze abiotic reactions, appear as important synthetic tools of synthetic biology field. This review describes the different strategies used for developing protein-based artificial enzymes for DA reaction, including for in cellulo approaches. 2

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Est décrite par hal-02984518 Image A. Jalila Simaan. approches en biologie synthétique pour générer des Diels Alderases artificielles. Computer graphics. France. 2020. ⟨hal-02984518⟩

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hal-02984513 , version 1 (10-11-2020)

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Wadih Ghattas, Jean-Pierre Mahy, Marius Réglier, A. Jalila Simaan. Artificial enzymes for Diels‐Alder reactions. ChemBioChem, 2021, 22 (3), pp.443-459. ⟨10.1002/cbic.202000316⟩. ⟨hal-02984513⟩
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