In this work, we propose a new concept of fail-safe switching cells based on the use of integrated fuses. These fuses allow the circuit to be partially isolated and reconfigured, which therefore becomes fault tolerant and prevents total shut down. We focused our work on the design and 3D simulation by finite elements method of monolithic fuses integrated on silicon substrate, taking into account static and dynamic specifications. Thermal management in steady state is improved by dielectric epoxy thermal insulation under each constriction of the fuse. Implementation and preliminary practical tests at medium voltage are reported. The effect of a coating using silicone gel around the fuses is analyzed to improve the cut-off capability.