Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Pediatrics Année : 2020

Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2

Résumé

Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19. Methods: We report two infants with possible maternofetal transmission, and four mothers without immunologic reactions. Data were collected from the patient files. Results: One mother exhibited infection signs 10 days before uncomplicated delivery, with negative RT-PCR and no antibody detection thereafter. Another mother exhibited infection 6 weeks pre-delivery, confirmed by nasopharyngeal swab testing with positive RT-PCR, and positive antibody detection (IgM and IgG). Both newborns were asymptomatic but tested positive for nasopharyngeal and stool RT-PCR at 1 and 3 days of age for the first one and at 1 day of age for stool analysis for the second one. Two additional mothers exhibited infection confirmed by positive RT-PCR testing at 28-and 31-days pre-delivery but did not present detectable antibody reaction at the time of delivery. Conclusion: These observations raise concerns regarding contamination risk by asymptomatic newborns and the efficacy of immunologic reactions in pregnant mothers, questioning the reliability of antibody testing during pregnancy.
Fichier principal
Vignette du fichier
Hascoet_Case series_COVID19_asymptomactic newborn_intrapartum transmission_fped-08-568979.pdf (148.76 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02977200 , version 2 (24-10-2020)
hal-02977200 , version 1 (17-06-2021)

Identifiants

Citer

J.M. Hascoët, Jean-Marc Jellimann, Cedric Hartard, Apolline Wittwer, Hélène Jeulin, et al.. Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2. Frontiers in Pediatrics, 2020, 8, pp.568979. ⟨10.3389/fped.2020.568979⟩. ⟨hal-02977200v2⟩
85 Consultations
111 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More