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Article Dans Une Revue Systematic Biology Année : 2020

The Multilocus Multispecies Coalescent: A Flexible New Model of Gene Family Evolution

Résumé

Incomplete lineage sorting (ILS), the interaction between coalescence and speciation, is a process which generates incongruences between gene trees and species trees, as do gene duplication (D), transfer (T) and loss (L). These processes are usually modelled independently, but in reality, ILS can affect gene copy number polymorphism, i.e., interfere with DTL. This has been previously recognised, but not treated in a satisfactory way, mainly because DTL events are naturally modelled forward-in-time, while ILS requires backward-in-time coalescent modelling. Here we consider the joint action of ILS and DTL on the gene tree/species tree problem in all its complexity. In particular, we show that the interaction between ILS and duplications/transfers only can result in patterns usually interpreted as resulting from gene loss, and that the realised rate of D, T and L becomes non-homogeneous in time when ILS is taken into account. We introduce algorithmic solutions to these problems. Our new model, the multilocus multispecies coalescent (MLMSC), which also accounts for any level of linkage between loci, generalises the multispecies coalescent model and offers a versatile, powerful framework for proper simulation and inference of gene family evolution.
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Dates et versions

hal-02972075 , version 1 (02-12-2020)

Identifiants

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Qiuyi Li, Celine Scornavacca, Nicolas Galtier, Yao-Ban Chan. The Multilocus Multispecies Coalescent: A Flexible New Model of Gene Family Evolution. Systematic Biology, 2020, ⟨10.1093/sysbio/syaa084⟩. ⟨hal-02972075⟩
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