This paper considers the problem of set-membership estimation for discrete-time linear time-varying descriptor systems subject to unknown but bounded disturbance and noise. We propose a set-membership estimation method based on a descriptor system observer and a zonotopic estimator of the observer error bounds. The observer parameters are optimized in order to minimize the sizes of the zonotopes enclosing all admissible state trajectories. Finally, two simulation results are provided to demonstrate the effectiveness of the proposed method.