In order to optimize ship navigation in the macrotidal Gironde Estuary, a recent project funded by the port of Bordeaux aims at better understand and forecast hydrodynamic and fine sediment transport within the estuary. In the framework of this project, a two-dimensional hydro-sedimentary model is built. The model includes hydrodynamic forcings, mixed-sediment transport, and consolidation processes. The harmonic analysis of the astronomical tides reveals a strong distortion of the tidal wave inducing the growth of overtide constituents and the non-significant effect of tide-surge interactions in annual-scale prediction. Depending on hydrological conditions, river discharge can considerably alter the model accuracy due to the migration of the turbidity maximum zone modifying the bottom roughness. Comparison with measurements shows the ability of the model to reproduce suspended-sediment concentrations in the central Estuary. Sensitivity of the model to sediment features has also been discussed in regard of suspended-sediment concentrations and fluid mud deposits. The model will be further coupled with ship squat predictions and a morphodynamic model.p { margin-bottom: 0.25 cm; line-height: 115%; }