Constitutive immune mechanisms: mediators of host defence and immune regulation - Archive ouverte HAL Access content directly
Journal Articles Nature Reviews Immunology Year : 2020

Constitutive immune mechanisms: mediators of host defence and immune regulation

Søren R. Paludan
  • Function : Author
Seth L. Masters
  • Function : Author
Trine H. Mogensen
  • Function : Author

Abstract

The immune system enables organisms to combat infections and to eliminate endogenous challenges. Immune responses can be evoked through diverse inducible pathways. However, various constitutive mechanisms are also required for immunocompetence. The inducible responses of pattern recognition receptors of the innate immune system and antigen-specific receptors of the adaptive immune system are highly effective, but they also have the potential to cause extensive immunopathology and tissue damage, as seen in many infectious and autoinflammatory diseases. By contrast, constitutive innate immune mechanisms, including restriction factors, basal autophagy and proteasomal degradation, tend to limit immune responses, with loss-of-function mutations in these pathways leading to inflammation. Although they function through a broad and heterogeneous set of mechanisms, the constitutive immune responses all function as early barriers to infection and aim to minimize any disruption of homeostasis. Supported by recent human and mouse data, in this Review we compare and contrast the inducible and constitutive mechanisms of immunosurveillance.
Fichier principal
Vignette du fichier
Paludan-Pradeu-Masters-Mogensen_Constitutive immune mechanisms_Mediators of host defence and immune regulation_Online version.pdf (1.01 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-02951558 , version 1 (28-09-2020)

Identifiers

Cite

Søren R. Paludan, Thomas Pradeu, Seth L. Masters, Trine H. Mogensen. Constitutive immune mechanisms: mediators of host defence and immune regulation. Nature Reviews Immunology, 2020, ⟨10.1038/s41577-020-0391-5⟩. ⟨hal-02951558⟩

Collections

CNRS HIPHISCITECH
45 View
45 Download

Altmetric

Share

Gmail Facebook X LinkedIn More