Correction: Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy
Ulrike Esslinger
(1)
,
Sophie Garnier
(1)
,
Agathe Korniat
(1)
,
Carole Proust
(1)
,
Georgios Kararigas
(2)
,
Martina Müller-Nurasyid
(3, 4, 5)
,
Jean-Philippe Empana
(6)
,
Michael P Morley
(7)
,
Claire Perret
(1)
,
Klaus Stark
(8)
,
Alexander G Bick
(9)
,
Sanjay K Prasad
(10)
,
Jennifer Kriebel
(3, 4)
,
Jin Li
(11)
,
Laurence Tiret
(1)
,
Konstantin Strauch
(3, 5)
,
Declan P O'Regan
(12)
,
Kenneth B Marguiles
(7)
,
Jonathan G Seidman
(13, 9)
,
Pierre Boutouyrie
(6, 14)
,
Patrick Lacolley
(15)
,
Xavier Jouven
(6, 14)
,
Christian Hengstenberg
(16, 17)
,
Michel Komajda
(1, 18)
,
Hakon Hakonarson
(11)
,
Richard Isnard
(1, 18)
,
Eloisa Arbustini
(19)
,
Harald Grallert
(3, 4)
,
Stuart A Cook
(20, 21, 22)
,
Christine E Seidman
(9, 13)
,
Vera Regitz-Zagrosek
(2)
,
Thomas P Cappola
(7)
,
Philippe Charron
(1, 18, 23)
,
François Cambien
(1)
,
Eric Villard
(1, 18)
1
ICAN -
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
2 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
3 Helmholtz Zentrum München = German Research Center for Environmental Health
4 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
5 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
6 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
7 Perelman School of Medicine
8 University of Regensburg
9 HMS - Harvard Medical School [Boston]
10 Royal Brompton Hospital
11 CHOP - Children’s Hospital of Philadelphia
12 Imperial College London
13 HHMI - Howard Hughes Medical Institute [Chevy Chase]
14 HEGP - Hôpital Européen Georges Pompidou [APHP]
15 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
16 DZHK - German Center for Cardiovascular Research
17 DHM - Deutsches Herzzentrum München
18 CHU Pitié-Salpêtrière [AP-HP]
19 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
20 NHCS - National Heart Centre Singapore
21 NHLI - National Heart and Lung Institute [London]
22 Duke-NUS Medical School [Singapore]
23 Hôpital Ambroise Paré [AP-HP]
2 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
3 Helmholtz Zentrum München = German Research Center for Environmental Health
4 German Research Center for Environmental Health - Helmholtz Center München (GmbH)
5 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
6 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
7 Perelman School of Medicine
8 University of Regensburg
9 HMS - Harvard Medical School [Boston]
10 Royal Brompton Hospital
11 CHOP - Children’s Hospital of Philadelphia
12 Imperial College London
13 HHMI - Howard Hughes Medical Institute [Chevy Chase]
14 HEGP - Hôpital Européen Georges Pompidou [APHP]
15 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
16 DZHK - German Center for Cardiovascular Research
17 DHM - Deutsches Herzzentrum München
18 CHU Pitié-Salpêtrière [AP-HP]
19 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
20 NHCS - National Heart Centre Singapore
21 NHLI - National Heart and Lung Institute [London]
22 Duke-NUS Medical School [Singapore]
23 Hôpital Ambroise Paré [AP-HP]
Sophie Garnier
- Fonction : Auteur
- PersonId : 934284
- IdHAL : sophie-garnier
- ORCID : 0000-0002-7492-1617
- IdRef : 031812910
Georgios Kararigas
- Fonction : Auteur
- PersonId : 784330
- ORCID : 0000-0002-8187-0176
Martina Müller-Nurasyid
- Fonction : Auteur
- PersonId : 773566
- ORCID : 0000-0003-3793-5910
Jean-Philippe Empana
- Fonction : Auteur
- PersonId : 760464
- ORCID : 0000-0002-1469-7772
- IdRef : 088628256
Klaus Stark
- Fonction : Auteur
- PersonId : 762616
- ORCID : 0000-0002-7832-1942
Patrick Lacolley
- Fonction : Auteur
- PersonId : 758275
- ORCID : 0000-0002-2938-1383
- IdRef : 09462447X
Christian Hengstenberg
- Fonction : Auteur
- PersonId : 762621
- ORCID : 0000-0002-8284-2994
Hakon Hakonarson
- Fonction : Auteur
- PersonId : 763145
- ORCID : 0000-0003-2814-7461
Richard Isnard
- Fonction : Auteur
- PersonId : 758420
- ORCID : 0000-0002-3439-8104
- IdRef : 050630733
Eloisa Arbustini
- Fonction : Auteur
- PersonId : 760654
- ORCID : 0000-0003-2948-7994
Vera Regitz-Zagrosek
- Fonction : Auteur
- PersonId : 761293
- ORCID : 0000-0002-3566-3467
Philippe Charron
- Fonction : Auteur
- PersonId : 766599
- IdHAL : philippe-charron
- ORCID : 0000-0002-1782-1118
- IdRef : 123379458
Résumé
Based on experiments conducted since this article's [1] publication, the authors have concluded that the protein-protein interaction results reported in Fig 4 are not reliable. In experiments done after the article was published, the authors observed signals for the negative control indicating that there was unspecific binding to the sepharose beads (S1 File). Furthermore, efforts to replicate the experiment using the transfection/co-immunoprecipita-tion protocol detailed in the article did not confirm the published results: a specific protein-protein interaction was not observed in co-immunoprecipitation experiments using native neonate cardiomyocyte extracts (S2 File). Given these findings, the result and conclusion statements referring to a physical interaction between BAG3 and HSPB7 are not supported. Specifically: • The penultimate sentence of the ZBTB17-HSPB7 locus subsection of the Results: "Using GST pull-down experiment and co-immunoprecipitation we also observed that recombinant BAG3 interacts with HSPB7 (Fig 4)." • The fifth sentence of the second paragraph of the Discussion section: "In addition, our in vitro experiments demonstrate a physical interaction of BAG3 with HSPB7 (Fig 4) suggesting functional relationships between the 2 proteins that may be relevant for their genetic implication in DCM pathophysiology." • The seventh sentence of the second paragraph of the Discussion section: "The interaction signal of BAG3 Arg151 and Cys151 isoforms with HSPB7 was similar (data not shown), suggesting no direct effect of the polymorphism on HSPB7 binding." A member of PLOS ONE's Editorial Board confirmed that the main conclusions of the article stand are not substantively affected by this issue.
Domaines
Sciences du Vivant [q-bio]
Origine : Publication financée par une institution
Loading...