Floods are considered as a major natural disaster due to their devastating effects that lead to socio-economic losses. The present study is an attempt to prepare a flood hazard susceptibility map of the Gabes region using ‘multi-criteria decision making – analytical hierarchy process’ model in geographic information system environment. Eight factors have been used in the flood modeling: elevation, land use/land cover, lithology, rainfall intensity, drainage density, distance from the drainage network, slope, and groundwater depth. The impact of each factor contributing in the flood risk was examined by weights using analytical hierarchy process method. The results obtained shows that the most prominent flood occurrence factor is the elevation (22.5%), around 15% of the total area is flooded and the flood hazard index is equal 6.30. The validation of results by a susceptibility zones histogram showed that 74.51% of the observed flood areas are mainly concentrated in a moderate to very high susceptibility zone.