<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02945525</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-02T18:54:09+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">A family of native amine dehydrogenases for the asymmetric reductive amination of ketones</title>
            <author role="aut">
              <persName>
                <forename type="first">Ombeline</forename>
                <surname>Mayol</surname>
              </persName>
              <idno type="idhal" notation="numeric">1341535</idno>
              <idno type="halauthorid" notation="string">2030251-1341535</idno>
              <idno type="IDREF">https://www.idref.fr/231811306</idno>
              <idno type="VIAF">https://viaf.org/viaf/204154440231135342701</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Karine</forename>
                <surname>Bastard</surname>
              </persName>
              <email type="md5">bca516b261be3e126094fa00394469c8</email>
              <email type="domain">univ-nantes.fr</email>
              <idno type="idhal" notation="numeric">1313954</idno>
              <idno type="halauthorid" notation="string">295839-1313954</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-4898-7871</idno>
              <idno type="IDREF">https://www.idref.fr/110807332</idno>
              <idno type="VIAF">https://viaf.org/viaf/213198864</idno>
              <idno type="ISNI">http://isni.org/isni/0000000359294843</idno>
              <affiliation ref="#struct-427676"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Lilian</forename>
                <surname>Beloti</surname>
              </persName>
              <idno type="halauthorid">2030252-0</idno>
              <affiliation ref="#struct-124942"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Amina</forename>
                <surname>Frese</surname>
              </persName>
              <idno type="halauthorid">2030253-0</idno>
              <affiliation ref="#struct-124942"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Johan P</forename>
                <surname>Turkenburg</surname>
              </persName>
              <idno type="halauthorid">1907193-0</idno>
              <affiliation ref="#struct-124942"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean-Louis</forename>
                <surname>Petit</surname>
              </persName>
              <email type="md5">d5cc9d2188d03fb421a62ac5fe43b467</email>
              <email type="domain">genoscope.cns.fr</email>
              <idno type="idhal" notation="string">jean-louis-petit</idno>
              <idno type="idhal" notation="numeric">911238</idno>
              <idno type="halauthorid" notation="string">203001-911238</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8566-0571</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Aline</forename>
                <surname>Mariage</surname>
              </persName>
              <idno type="idhal" notation="numeric">1374784</idno>
              <idno type="halauthorid" notation="string">1182821-1374784</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-4423-818X</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Adrien</forename>
                <surname>Debard</surname>
              </persName>
              <idno type="idhal" notation="numeric">1522016</idno>
              <idno type="halauthorid" notation="string">1008855-1522016</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-7229-2060</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Virginie</forename>
                <surname>Pellouin</surname>
              </persName>
              <idno type="idhal" notation="numeric">1524087</idno>
              <idno type="halauthorid" notation="string">1226196-1524087</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-0468-2507</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Alain</forename>
                <surname>Perret</surname>
              </persName>
              <email type="md5">3bde9c88d0c21df53c790a25fb6bdb64</email>
              <email type="domain">genoscope.cns.fr</email>
              <idno type="idhal" notation="string">aperret</idno>
              <idno type="idhal" notation="numeric">1329361</idno>
              <idno type="halauthorid" notation="string">1264402-1329361</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-8896-1978</idno>
              <idno type="IDREF">https://www.idref.fr/185545688</idno>
              <idno type="VIAF">https://viaf.org/viaf/316037404</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Véronique</forename>
                <surname>de Berardinis</surname>
              </persName>
              <email type="md5">090d465af4fecf2f9aeff7cefc9c4e39</email>
              <email type="domain">genoscope.cns.fr</email>
              <idno type="idhal" notation="string">de-berardinis-veronique</idno>
              <idno type="idhal" notation="numeric">1146372</idno>
              <idno type="halauthorid" notation="string">358152-1146372</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-3273-4135</idno>
              <idno type="IDREF">https://www.idref.fr/11507869X</idno>
              <idno type="VIAF">https://viaf.org/viaf/197218229</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Anne</forename>
                <surname>Zaparucha</surname>
              </persName>
              <email type="md5">b0b6cd71be09ea34774a81faa3558950</email>
              <email type="domain">genoscope.cns.fr</email>
              <idno type="idhal" notation="string">anne-zaparucha</idno>
              <idno type="idhal" notation="numeric">739626</idno>
              <idno type="halauthorid" notation="string">305973-739626</idno>
              <idno type="IDREF">https://www.idref.fr/155946307</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-2531-4148</idno>
              <idno type="VIAF">https://viaf.org/viaf/305294952</idno>
              <idno type="ISNI">http://isni.org/isni/000000041890258X</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Gideon</forename>
                <surname>Grogan</surname>
              </persName>
              <email type="md5">5e495d25101fb09909f89869e2771c58</email>
              <email type="domain">ysbl.york.ac.uk</email>
              <idno type="idhal" notation="numeric">870289</idno>
              <idno type="halauthorid" notation="string">459109-870289</idno>
              <affiliation ref="#struct-124942"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Carine</forename>
                <surname>Vergne-Vaxelaire</surname>
              </persName>
              <email type="md5">d3b23decbb193fd8ec74f6fa177b105d</email>
              <email type="domain">genoscope.cns.fr</email>
              <idno type="idhal" notation="string">carine-vergne-vaxelaire</idno>
              <idno type="idhal" notation="numeric">737135</idno>
              <idno type="halauthorid" notation="string">40730-737135</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-1202-8110</idno>
              <idno type="IDREF">https://www.idref.fr/110830393</idno>
              <idno type="VIAF">https://viaf.org/viaf/214287703</idno>
              <idno type="ISNI">http://isni.org/isni/0000000139470796</idno>
              <affiliation ref="#struct-21582"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Carine</forename>
                <surname>Vergne-Vaxelaire</surname>
              </persName>
              <email type="md5">d3b23decbb193fd8ec74f6fa177b105d</email>
              <email type="domain">genoscope.cns.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2020-09-22 13:47:20</date>
              <date type="whenModified">2025-04-17 10:04:02</date>
              <date type="whenReleased">2020-09-24 14:34:36</date>
              <date type="whenProduced">2019</date>
              <date type="whenEndEmbargoed">2020-09-22</date>
              <ref type="file" target="https://hal.science/hal-02945525v1/document">
                <date notBefore="2020-09-22"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02945525v1/file/Vergne-Vaxelaire_maintext_unmarked.pdf" id="file-2945525-2595789">
                <date notBefore="2020-09-22"/>
              </ref>
              <ref type="externalLink" target="http://eprints.whiterose.ac.uk/143845/1/Vergne_Vaxelaire_Accepted_Author_Manuscript.docx"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="929813">
                <persName>
                  <forename>Carine</forename>
                  <surname>Vergne-Vaxelaire</surname>
                </persName>
                <email type="md5">d3b23decbb193fd8ec74f6fa177b105d</email>
                <email type="domain">genoscope.cns.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02945525</idno>
            <idno type="halUri">https://hal.science/hal-02945525</idno>
            <idno type="halBibtex">mayol:hal-02945525</idno>
            <idno type="halRefHtml">&lt;i&gt;Nature Catalysis&lt;/i&gt;, 2019, 2 (4), pp.324-333. &lt;a target="_blank" href="https://dx.doi.org/10.1038/s41929-019-0249-z"&gt;&amp;#x27E8;10.1038/s41929-019-0249-z&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Nature Catalysis, 2019, 2 (4), pp.324-333. &amp;#x27E8;10.1038/s41929-019-0249-z&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://about.hal.science/hal-authorisation-v1/">HAL Authorization<ref corresp="#file-2945525-2595789"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-EVRY">Université d'Evry-Val d'Essonne</idno>
            <idno type="stamp" n="DSV-IG" corresp="CEA">Institut de Génomique d'Evry</idno>
            <idno type="stamp" n="DSV" corresp="CEA">Direction de la recherche fondamentale - sciences du vivant</idno>
            <idno type="stamp" n="CEA-UPSAY" corresp="CEA">CEA - Université Paris-Saclay</idno>
            <idno type="stamp" n="GENOMIQUE-METABOLIQUE" corresp="UNIV-EVRY">Génomique Métabolique</idno>
            <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno>
            <idno type="stamp" n="UNIV-EVRY-SACLAY" corresp="UNIV-PARIS-SACLAY">UNIV-EVRY-SACLAY</idno>
            <idno type="stamp" n="CEA-UPSAY-SACLAY" corresp="CEA">CEA-UPSAY-SACLAY</idno>
            <idno type="stamp" n="JACOB" corresp="CEA">Institut de Biologie François JACOB</idno>
            <idno type="stamp" n="CEA-DRF" corresp="CEA">Direction de Recherche Fondamentale</idno>
            <idno type="stamp" n="GENOSCOPE" corresp="CEA">Génoscope-CNS</idno>
            <idno type="stamp" n="TEST-HALCNRS">Collection test HAL CNRS</idno>
            <idno type="stamp" n="GS-BIOSPHERA">Graduate School Biologie, Société, Ecologie &amp; Environnement, Ressources, Agriculture &amp; Alimentation</idno>
            <idno type="stamp" n="APT_TEST">APT_TEST</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">A family of native amine dehydrogenases for the asymmetric reductive amination of ketones</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Ombeline</forename>
                    <surname>Mayol</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1341535</idno>
                  <idno type="halauthorid" notation="string">2030251-1341535</idno>
                  <idno type="IDREF">https://www.idref.fr/231811306</idno>
                  <idno type="VIAF">https://viaf.org/viaf/204154440231135342701</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Karine</forename>
                    <surname>Bastard</surname>
                  </persName>
                  <email type="md5">bca516b261be3e126094fa00394469c8</email>
                  <email type="domain">univ-nantes.fr</email>
                  <idno type="idhal" notation="numeric">1313954</idno>
                  <idno type="halauthorid" notation="string">295839-1313954</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-4898-7871</idno>
                  <idno type="IDREF">https://www.idref.fr/110807332</idno>
                  <idno type="VIAF">https://viaf.org/viaf/213198864</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000359294843</idno>
                  <affiliation ref="#struct-427676"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Lilian</forename>
                    <surname>Beloti</surname>
                  </persName>
                  <idno type="halauthorid">2030252-0</idno>
                  <affiliation ref="#struct-124942"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Amina</forename>
                    <surname>Frese</surname>
                  </persName>
                  <idno type="halauthorid">2030253-0</idno>
                  <affiliation ref="#struct-124942"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Johan P</forename>
                    <surname>Turkenburg</surname>
                  </persName>
                  <idno type="halauthorid">1907193-0</idno>
                  <affiliation ref="#struct-124942"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean-Louis</forename>
                    <surname>Petit</surname>
                  </persName>
                  <email type="md5">d5cc9d2188d03fb421a62ac5fe43b467</email>
                  <email type="domain">genoscope.cns.fr</email>
                  <idno type="idhal" notation="string">jean-louis-petit</idno>
                  <idno type="idhal" notation="numeric">911238</idno>
                  <idno type="halauthorid" notation="string">203001-911238</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8566-0571</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Aline</forename>
                    <surname>Mariage</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1374784</idno>
                  <idno type="halauthorid" notation="string">1182821-1374784</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-4423-818X</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Adrien</forename>
                    <surname>Debard</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1522016</idno>
                  <idno type="halauthorid" notation="string">1008855-1522016</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-7229-2060</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Virginie</forename>
                    <surname>Pellouin</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">1524087</idno>
                  <idno type="halauthorid" notation="string">1226196-1524087</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-0468-2507</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Alain</forename>
                    <surname>Perret</surname>
                  </persName>
                  <email type="md5">3bde9c88d0c21df53c790a25fb6bdb64</email>
                  <email type="domain">genoscope.cns.fr</email>
                  <idno type="idhal" notation="string">aperret</idno>
                  <idno type="idhal" notation="numeric">1329361</idno>
                  <idno type="halauthorid" notation="string">1264402-1329361</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-8896-1978</idno>
                  <idno type="IDREF">https://www.idref.fr/185545688</idno>
                  <idno type="VIAF">https://viaf.org/viaf/316037404</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Véronique</forename>
                    <surname>de Berardinis</surname>
                  </persName>
                  <email type="md5">090d465af4fecf2f9aeff7cefc9c4e39</email>
                  <email type="domain">genoscope.cns.fr</email>
                  <idno type="idhal" notation="string">de-berardinis-veronique</idno>
                  <idno type="idhal" notation="numeric">1146372</idno>
                  <idno type="halauthorid" notation="string">358152-1146372</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-3273-4135</idno>
                  <idno type="IDREF">https://www.idref.fr/11507869X</idno>
                  <idno type="VIAF">https://viaf.org/viaf/197218229</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Anne</forename>
                    <surname>Zaparucha</surname>
                  </persName>
                  <email type="md5">b0b6cd71be09ea34774a81faa3558950</email>
                  <email type="domain">genoscope.cns.fr</email>
                  <idno type="idhal" notation="string">anne-zaparucha</idno>
                  <idno type="idhal" notation="numeric">739626</idno>
                  <idno type="halauthorid" notation="string">305973-739626</idno>
                  <idno type="IDREF">https://www.idref.fr/155946307</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-2531-4148</idno>
                  <idno type="VIAF">https://viaf.org/viaf/305294952</idno>
                  <idno type="ISNI">http://isni.org/isni/000000041890258X</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Gideon</forename>
                    <surname>Grogan</surname>
                  </persName>
                  <email type="md5">5e495d25101fb09909f89869e2771c58</email>
                  <email type="domain">ysbl.york.ac.uk</email>
                  <idno type="idhal" notation="numeric">870289</idno>
                  <idno type="halauthorid" notation="string">459109-870289</idno>
                  <affiliation ref="#struct-124942"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Carine</forename>
                    <surname>Vergne-Vaxelaire</surname>
                  </persName>
                  <email type="md5">d3b23decbb193fd8ec74f6fa177b105d</email>
                  <email type="domain">genoscope.cns.fr</email>
                  <idno type="idhal" notation="string">carine-vergne-vaxelaire</idno>
                  <idno type="idhal" notation="numeric">737135</idno>
                  <idno type="halauthorid" notation="string">40730-737135</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-1202-8110</idno>
                  <idno type="IDREF">https://www.idref.fr/110830393</idno>
                  <idno type="VIAF">https://viaf.org/viaf/214287703</idno>
                  <idno type="ISNI">http://isni.org/isni/0000000139470796</idno>
                  <affiliation ref="#struct-21582"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">127767</idno>
                <idno type="issn">2520-1158</idno>
                <title level="j">Nature Catalysis</title>
                <imprint>
                  <publisher>Nature Publishing Group</publisher>
                  <biblScope unit="volume">2</biblScope>
                  <biblScope unit="issue">4</biblScope>
                  <biblScope unit="pp">324-333</biblScope>
                  <date type="datePub">2019</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1038/s41929-019-0249-z</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="chim.orga">Chemical Sciences/Organic chemistry</classCode>
              <classCode scheme="halDomain" n="chim.cata">Chemical Sciences/Catalysis</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bs">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bc">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdv.bio">Life Sciences [q-bio]/Biotechnology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>The asymmetric reductive amination of ketones enables the one-step synthesis of chiral amines from readily available starting materials. Here we report the discovery of a family of native NAD(P)H-dependent amine dehydrogenases (nat-AmDHs) competent for the asymmetric reductive amination of aliphatic and alicyclic ketones, adding significantly to the biocatalytic toolbox available for chiral amine synthesis. Studies of ketone and amine substrate specificity and kinetics reveal a strong preference for aliphatic ketones and aldehydes, with activities of up to 614.5 mU mg−1 for cyclohexanone with ammonia, and 851.3 mU mg−1 for isobutyraldehyde with methylamine as the amine donor. Crystal structures of three nat-AmDHs (AmDH4, MsmeAmDH and CfusAmDH) reveal the active site determinants of substrate and cofactor specificity and enable the rational engineering of AmDH4 for the generated activity towards pentan-2-one. Analysis of the three-dimensional catalytic site distribution among bacterial biodiversity revealed a superfamily of divergent proteins with representative specificities ranging from amino acid substrates to hydrophobic ketones.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="department" xml:id="struct-21582" status="VALID">
          <idno type="IdRef">200714651</idno>
          <idno type="ISNI">0000 0004 0370 4353</idno>
          <idno type="RNSR">200012703M</idno>
          <idno type="ROR">https://ror.org/00xc55v17</idno>
          <idno type="Wikidata">Q51785052</idno>
          <orgName>Génomique métabolique</orgName>
          <orgName type="acronym">UMR 8030</orgName>
          <date type="start">2020-01-01</date>
          <desc>
            <address>
              <addrLine>GENOSCOPE, 2 rue Gaston Crémieux 91057 Evry Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.genoscope.cns.fr/spip/UMR-8030-de-Genomique-metabolique.html</ref>
          </desc>
          <listRelation>
            <relation name="DRF/JACOB" active="#struct-55375" type="direct"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation name="DRF/JACOB" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-300306" type="direct"/>
            <relation name="UMR8030" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-427676" status="VALID">
          <orgName>Analyse Bio-Informatique pour la Génomique et le Métabolisme</orgName>
          <orgName type="acronym">LABGeM</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="DRF/JACOB" active="#struct-21582" type="direct"/>
            <relation name="DRF/JACOB" active="#struct-55375" type="indirect"/>
            <relation active="#struct-419361" type="indirect"/>
            <relation name="DRF/JACOB" active="#struct-465913" type="indirect"/>
            <relation active="#struct-300016" type="indirect"/>
            <relation active="#struct-300306" type="indirect"/>
            <relation name="UMR8030" active="#struct-441569" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-124942" status="VALID">
          <idno type="ROR">https://ror.org/04m01e293</idno>
          <orgName>University of York [York, UK]</orgName>
          <desc>
            <address>
              <addrLine>Heslington, York, YO10 5DD</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.york.ac.uk/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-55375" status="VALID">
          <orgName>Genoscope - Centre national de séquençage [Evry]</orgName>
          <orgName type="acronym">GENOSCOPE</orgName>
          <desc>
            <address>
              <addrLine>2, rue Gaston Crémieux CP5706 91057 EVRY Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.genoscope.cns.fr</ref>
          </desc>
          <listRelation>
            <relation active="#struct-419361" type="direct"/>
            <relation name="DRF/JACOB" active="#struct-465913" type="direct"/>
            <relation active="#struct-300016" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-419361" status="VALID">
          <idno type="IdRef">241345251</idno>
          <idno type="ROR">https://ror.org/03xjwb503</idno>
          <orgName>Université Paris-Saclay</orgName>
          <desc>
            <address>
              <addrLine>Bâtiment Bréguet, 3 Rue Joliot Curie 2e ét, 91190 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.universite-paris-saclay.fr/fr</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-465913" status="VALID">
          <idno type="IdRef">251118436</idno>
          <idno type="RNSR">201622496M</idno>
          <idno type="ROR">https://ror.org/01yvj5k91</idno>
          <idno type="Wikidata">Q52604525</idno>
          <orgName>Direction de Recherche Fondamentale (CEA)</orgName>
          <orgName type="acronym">DRF (CEA)</orgName>
          <date type="start">2016-01-01</date>
          <desc>
            <address>
              <addrLine>Direction de Recherche FondamentaleFundamental Research DivisionCEA Saclay91191 Gif-sur-Yvette</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ceasciences.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300016" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300016" status="VALID">
          <idno type="IdRef">026372061</idno>
          <idno type="ISNI">0000000122998025</idno>
          <idno type="ROR">https://ror.org/00jjx8s55</idno>
          <idno type="Wikidata">Q868550</idno>
          <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
          <orgName type="acronym">CEA</orgName>
          <desc>
            <address>
              <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.cea.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300306" status="VALID">
          <idno type="IdRef">030820529</idno>
          <idno type="ISNI">0000000121805818</idno>
          <idno type="ROR">https://ror.org/00e96v939</idno>
          <idno type="Wikidata">Q1531014</idno>
          <orgName>Université d'Évry-Val-d'Essonne</orgName>
          <orgName type="acronym">UEVE</orgName>
          <date type="start">1991-07-22</date>
          <desc>
            <address>
              <addrLine>Boulevard François Mitterrand 91025 Evry Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-evry.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>