Article Dans Une Revue Angewandte Chemie International Edition Année : 2017

Radical-Based C-C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines

Luca Buzzetti
  • Fonction : Auteur
Sudipta Raha Roy
  • Fonction : Auteur
Paolo Melchiorre
  • Fonction : Auteur

Résumé

We report herein that 4-alkyl-1,4-dihydropyridines (alkyl-DHPs) can directly reach an electronically excited state upon light absorption and trigger the generation of C(sp3)- centered radicals without the need for an external photocatalyst. Selective excitation with a violet-light-emitting diode turns alkyl-DHPs into strong reducing agents that can activate reagents through single-electron transfer manifolds while undergoing homolytic cleavage to generate radicals. We used this photochemical dual-reactivity profile to trigger radicalbased carbon–carbon bond-forming processes, including nickel-catalyzed cross-coupling reactions.

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Dates et versions

hal-02943306 , version 1 (23-09-2020)

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Citer

Luca Buzzetti, Alexis Prieto, Sudipta Raha Roy, Paolo Melchiorre. Radical-Based C-C Bond-Forming Processes Enabled by the Photoexcitation of 4-Alkyl-1,4-dihydropyridines. Angewandte Chemie International Edition, 2017, 56, pp.15039-15043. ⟨10.1002/anie.201709571⟩. ⟨hal-02943306⟩
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