Article Dans Une Revue Applied and Environmental Microbiology Année : 2009

High-Level Biosynthesis of the Anteiso-C17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity

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High-level production (880 mg liter−1) and isolation of the anteiso-C17 isoform of the lipopeptide mycosubtilin produced by a genetically engineered Bacillus subtilis strain are reported. Antifungal activity of this isoform, as determined via culture and fluorometric and cell leakage assays, suggests its potential therapeutic use as an antifungal agent, in particular against Candida spp

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hal-02941974 , version 1 (17-09-2020)

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Patrick Fickers, Jean-Sebastien Guez, Christian Damblon, Valérie Leclère, Max Béchet, et al.. High-Level Biosynthesis of the Anteiso-C17 Isoform of the Antibiotic Mycosubtilin in Bacillus subtilis and Characterization of Its Candidacidal Activity. Applied and Environmental Microbiology, 2009, 75 (13), pp.4636-4640. ⟨10.1128/AEM.00548-09⟩. ⟨hal-02941974⟩
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