Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study - Archive ouverte HAL Access content directly
Journal Articles European Archives of Oto-Rhino-Laryngology Year : 2020

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

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Daniele R. de Siati
  • Function : Author
Mihaela Horoi
  • Function : Author
Serge Daniel Le Bon
  • Function : Author
Alexandra Rodriguez
  • Function : Author
Didier Dequanter
  • Function : Author
Serge A. Blecic
  • Function : Author
Irene Lõpez Delgado
  • Function : Author
Christian E. Calvo-Henriquez
Philippe Lavigne
  • Function : Author
  • PersonId : 779198
  • IdRef : 187246939
Chiara Falanga
  • Function : Author
Maria Rosaria Barillari
Giovanni Cammaroto
Mohamad Khalife
  • Function : Author
Pierre Leich
  • Function : Author
Christel Souchay
  • Function : Author
Camélia Rossi
  • Function : Author
Fabrice Journe
  • Function : Author
Julien Wen Hsieh
Laurence Ris
Andrea Lovato
Cosimo de Filippis
  • Function : Author
Frédérique Coppee
  • Function : Author
Tareck Ayad
Sven Saussez

Abstract

Objective: To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods: Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). Results: A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001). Conclusion: Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.

Dates and versions

hal-02938438 , version 1 (14-09-2020)

Identifiers

Cite

Jér̂ome René Lechien, Carlos Miguel Chiesa-Estomba, Daniele R. de Siati, Mihaela Horoi, Serge Daniel Le Bon, et al.. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-Rhino-Laryngology, 2020, 277 (8), pp.2251-2261. ⟨10.1007/s00405-020-05965-1⟩. ⟨hal-02938438⟩
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