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Article Dans Une Revue European Archives of Oto-Rhino-Laryngology Année : 2020

Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study

Daniele R. de Siati
  • Fonction : Auteur
Mihaela Horoi
  • Fonction : Auteur
Serge Daniel Le Bon
  • Fonction : Auteur
Alexandra Rodriguez
  • Fonction : Auteur
Didier Dequanter
  • Fonction : Auteur
Serge A. Blecic
  • Fonction : Auteur
Irene Lõpez Delgado
  • Fonction : Auteur
Christian E. Calvo-Henriquez
Philippe Lavigne
  • Fonction : Auteur
  • PersonId : 779198
  • IdRef : 187246939
Chiara Falanga
  • Fonction : Auteur
Maria Rosaria Barillari
Giovanni Cammaroto
Mohamad Khalife
  • Fonction : Auteur
Pierre Leich
  • Fonction : Auteur
Christel Souchay
  • Fonction : Auteur
Camélia Rossi
  • Fonction : Auteur
Fabrice Journe
  • Fonction : Auteur
Julien Wen Hsieh
Laurence Ris
Andrea Lovato
Cosimo de Filippis
  • Fonction : Auteur
Frédérique Coppee
  • Fonction : Auteur
Tareck Ayad
Sven Saussez

Résumé

Objective: To investigate the occurrence of olfactory and gustatory dysfunctions in patients with laboratory-confirmed COVID-19 infection. Methods: Patients with laboratory-confirmed COVID-19 infection were recruited from 12 European hospitals. The following epidemiological and clinical outcomes have been studied: age, sex, ethnicity, comorbidities, and general and otolaryngological symptoms. Patients completed olfactory and gustatory questionnaires based on the smell and taste component of the National Health and Nutrition Examination Survey, and the short version of the Questionnaire of Olfactory Disorders-Negative Statements (sQOD-NS). Results: A total of 417 mild-to-moderate COVID-19 patients completed the study (263 females). The most prevalent general symptoms consisted of cough, myalgia, and loss of appetite. Face pain and nasal obstruction were the most disease-related otolaryngological symptoms. 85.6% and 88.0% of patients reported olfactory and gustatory dysfunctions, respectively. There was a significant association between both disorders (p < 0.001). Olfactory dysfunction (OD) appeared before the other symptoms in 11.8% of cases. The sQO-NS scores were significantly lower in patients with anosmia compared with normosmic or hyposmic individuals (p = 0.001). Among the 18.2% of patients without nasal obstruction or rhinorrhea, 79.7% were hyposmic or anosmic. The early olfactory recovery rate was 44.0%. Females were significantly more affected by olfactory and gustatory dysfunctions than males (p = 0.001). Conclusion: Olfactory and gustatory disorders are prevalent symptoms in European COVID-19 patients, who may not have nasal symptoms. The sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
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Dates et versions

hal-02938438 , version 1 (27-10-2023)

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Jér̂ome René Lechien, Carlos Miguel Chiesa-Estomba, Daniele R. de Siati, Mihaela Horoi, Serge Daniel Le Bon, et al.. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. European Archives of Oto-Rhino-Laryngology, 2020, 277 (8), pp.2251-2261. ⟨10.1007/s00405-020-05965-1⟩. ⟨hal-02938438⟩
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