Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin - Archive ouverte HAL
Article Dans Une Revue Biomacromolecules Année : 2020

Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin

Résumé

Chondroitin sulfate type-E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as modulation of the neuronal growth factor signaling and its interaction with langerin, a C-type lectin with a crucial role in the immunological system. However, applications of CS-E are hampered by the typical heterogeneous structure of the natural polysaccharide. Well-defined, homogeneous CS-E analogues are highly demanded. Here, we report the synthesis of monodispersed, structurally well-defined second-generation glycodendrimers displaying up to 18 CS-E disaccharide units. These complex multivalent systems have a molecular weight and a number of disaccharide repeating units comparable with those of the natural polysaccharides. In addition, surface plasmon resonance experiments revealed a calcium-independent interaction between these glycodendrimers and langerin, in the micromolar range, highlighting the utility of these compounds as CS-E mimetics.

Dates et versions

hal-02934468 , version 1 (09-09-2020)

Identifiants

Citer

Pedro Domínguez-Rodríguez, Corinne Vivès, Michel Thepaut, Franck Fieschi, Pedro Nieto, et al.. Second-Generation Dendrimers with Chondroitin Sulfate Type-E Disaccharides as Multivalent Ligands for Langerin. Biomacromolecules, 2020, 21 (7), pp.2726-2734. ⟨10.1021/acs.biomac.0c00476⟩. ⟨hal-02934468⟩
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