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Chapitre D'ouvrage Année : 2019

Fourier transform ion cyclotron resonance mass spectrometry and laser: A versatile tool

Résumé

Among the numerous ion sources coupled to Fourier transform ion cyclotron resonance mass spectrometers, the laser-based ion sources have a key role. Pulsed lasers have the unique ability to generate neutrals and/or ions from a condensed or gaseous sample in a non-invasive way and to be focused on a very thin area. Depending on both the laser beam and the sample features, various processes could happen during laser–matter interaction that directly impact the detected ions. In this chapter, the factors driving this interaction will be firstly described especially to understand that leading to: the laser desorption (LD), desorption/ionization with (MALDI) or without (LDI) matrix assistance and the laser ablation (LA). The resulting technical advances of laser ion sources, including those, which operate under atmospheric pressure are explained in detail in this chapter for achieving robust FT-ICR-MS measurements. The advent of high performance imaging mass spectrometry using laser ion sources also push up some new developments which will be summarized. A great number of applications demonstrate the versatility of the combination of laser and FT-ICR-MS and some of them will be illustrated in a last section.
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Dates et versions

hal-02923084 , version 1 (26-08-2020)

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Citer

Frédéric Aubriet, Vincent Carré. Fourier transform ion cyclotron resonance mass spectrometry and laser: A versatile tool. Basem Kanawati; Philippe Schmitt-Kopplin. Fundamentals and Applications of Fourier Transform Mass Spectrometry, Elsevier, pp.281-322, 2019, 978-0-12-814013-0. ⟨10.1016/B978-0-12-814013-0.00010-7⟩. ⟨hal-02923084⟩
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