While the Atlantic Meridional Overturning Circulation (AMOC) is projected to slow down under anthropogenic warming, the exact role of the AMOC in future climate change has not been fully quantified. Here, we present a method to stabilize the AMOC intensity in anthropogenic warming experiments by removing fresh water from the subpolar North Atlantic. This method enables us to isolate the AMOC climatic impacts in experiments with a fullphysics climate model. Our results show that a weakened AMOC can explain ocean cooling south of Greenland that resembles the North Atlantic warming hole and a reduced Arctic sea ice loss in all seasons with a delay of about 6 years in the emergence of an ice-free Arctic in boreal summer. In the troposphere, a weakened AMOC causes an anomalous cooling band stretching from the lower levels in high latitudes to the upper levels in the tropics and displaces the Northern Hemisphere midlatitude jets poleward.