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Article Dans Une Revue Science Advances Année : 2020

Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective

Sandrine Dufort
Johan Pietras
  • Fonction : Auteur
Irène Troprès
Sébastien Mériaux
Benoit Larrat
  • Fonction : Auteur

Résumé

The use of radiosensitizing nanoparticles with both imaging and therapeutic properties on the same nano-object is regarded as a major and promising approach to improve the effectiveness of radiotherapy. Here, we report the MRI findings of a phase 1 clinical trial with a single intravenous administration of Gd-based AGuIX nanoparticles, conducted in 15 patients with four types of brain metastases (melanoma, lung, colon, and breast). The nanoparticles were found to accumulate and to increase image contrast in all types of brain metastases with MRI enhancements equivalent to that of a clinically used contrast agent. The presence of nanoparticles in metastases was monitored and quantified with MRI and was noticed up to 1 week after their administration. To take advantage of the radiosensitizing property of the nanoparticles, patients underwent radiotherapy sessions following their administration. This protocol has been extended to a multicentric phase 2 clinical trial including 100 patients.
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Dates et versions

hal-02919837 , version 1 (03-12-2020)

Identifiants

Citer

Camille Verry, Sandrine Dufort, Benjamin Lemasson, Sylvie Grand, Johan Pietras, et al.. Targeting brain metastases with ultrasmall theranostic nanoparticles, a first-in-human trial from an MRI perspective. Science Advances , 2020, 6 (29), pp.eaay5279. ⟨10.1126/sciadv.aay5279⟩. ⟨hal-02919837⟩
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