Article Dans Une Revue Frontiers in Cellular and Infection Microbiology Année : 2019

Microglial Cells: The Main HIV-1 Reservoir in the Brain

Résumé

Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. Hidden HIV-1 in cellular and anatomic reservoirs is the major hurdle toward a functional cure. Microglial cells, the Central Nervous system (CNS) resident macrophages, are one of the major cellular reservoirs of latent HIV-1. These cells are believed to be involved in the emergence of drugs resistance and reseeding peripheral tissues. Moreover, these long-life reservoirs are also involved in the development of HIV-1-associated neurocognitive diseases (HAND). Clearing these infected cells from the brain is therefore crucial to achieve a cure. However, many characteristics of microglial cells and the CNS hinder the eradication of these brain reservoirs. Better understandings of the specific molecular mechanisms of HIV-1 latency in microglial cells should help to design new molecules and new strategies preventing HAND and achieving HIV cure. Moreover, new strategies are needed to circumvent the limitations associated to anatomical sanctuaries with barriers such as the blood brain barrier (BBB) that reduce the access of drugs.

Fichier principal
Vignette du fichier
islandora_92844.pdf (1.5 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence
Loading...

Dates et versions

hal-02917276 , version 1 (18-08-2020)

Licence

Identifiants

Citer

Clémentine Wallet, Marco de Rovere, Jeanne van Assche, Fadoua Daouad, Stéphane de Wit, et al.. Microglial Cells: The Main HIV-1 Reservoir in the Brain. Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.362. ⟨10.3389/fcimb.2019.00362⟩. ⟨hal-02917276⟩
78 Consultations
175 Téléchargements

Altmetric

Partager

  • More