Formulation induces direct DNA UV-A photooxidation. Part II. Pro-oxidant effect of formulated Vitamin E via generation of singlet oxygen

HIGHLIGHTS · Cetyltriethylammonium bromide (CTEAB) and Vitamin E self-assemble in TRIS/HCl buffer solutions into nanoemulsion composed of CTEAB micelles (that can incorporate Vitamin E) as well as larger Vitamin E droplets. · CTEAB-Vitamin E nanoemulsion interacts with plasmid DNA pBR322 and the gradual DNA compaction followed by gradual DNA decompaction for increasing CTEAB-Vitamin E amounts have been highlighted. · UVA irradiation induces photooxidation of DNA on the formulated CTEAB-Vitamin E-DNA lipoplex and underlines the pro-oxidant role of the Vitamin E in this self-assembled system.

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Chimie

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Teychene_JMolLiq_2020 HAL version.pdf (2.2 Mo)

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Christophe Dejugnat : Connectez-vous pour contacter le contributeur

https://hal.science/hal-02916908

Soumis le : vendredi 6 novembre 2020-14:58:13

Dernière modification le : jeudi 14 novembre 2024-03:29:05

Archivage à long terme le : dimanche 7 février 2021-19:32:27

Dates et versions

hal-02916908 , version 1 (06-11-2020)

Identifiants

HAL Id : hal-02916908 , version 1
DOI : 10.1016/j.molliq.2020.113818
WOS : 000568693000075

Citer

Johanne Teychené, Dalina Didacus-Prins, Nadia Chouini-Lalanne, Christophe Dejugnat, Valérie Sartor. Formulation induces direct DNA UV-A photooxidation. Part II. Pro-oxidant effect of formulated Vitamin E via generation of singlet oxygen. Journal of Molecular Liquids, 2020, 316, pp.113818. ⟨10.1016/j.molliq.2020.113818⟩. ⟨hal-02916908⟩

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