Dynamics of proteins in solution - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Quarterly Reviews of Biophysics Année : 2019

Dynamics of proteins in solution

Résumé

The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.

Dates et versions

hal-02915836 , version 1 (16-08-2020)

Identifiants

Citer

Marco Grimaldo, Felix Roosen-Runge, Fajun Zhang, Frank Schreiber, Tilo Seydel. Dynamics of proteins in solution. Quarterly Reviews of Biophysics, 2019, 52, pp.e7. ⟨10.1017/S0033583519000027⟩. ⟨hal-02915836⟩

Collections

ANR
28 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More