Quantitative ultrasound can be used to characterize the evolution of the bone-implant interface (BII), which is a complex system due to the implant surface roughness and to partial contact between bone and the implant. The determination of the constitutive law of the BII would be of interest in the context of implant acoustical modeling in order to take into account the imperfect characteristics of the BII. The aim of the present study is to propose an analytical effective model describing the interaction between an ultrasonic wave and a rough BII. To do so, a spring model was considered to determine the equivalent stiffness K of the BII. The stiffness contributions related (i) to the partial contact between the bone and the implant and (ii) to the presence of soft tissues at the BII during the process of osseointegration were assessed independently. K was found to be comprised between 10 13 and 10 17 N/m 3 depending on the roughness and osseointegration of the BII. Analytical values of reflection and transmission coefficients at the BII were derived from values of K. A good agreement with numerical results obtained through finite element simulation was obtained. This model may be used for future finite element bone-implant models to replace the BII conditions.