TRANSCRIPTIONAL REGULATION OF THE 11P15 MUCIN GENES. TOWARDS NEW BIOLOGICAL TOOLS IN HUMAN THERAPY, IN INFLAMMATORY DISEASES AND CANCER?
Résumé
TABLE OF CONTENTS 1. Abstract 2. Introduction 3. 11p15 mucin gene expression is cell-and tissue-specific 4. Organization of the 11p15 mucin gene cluster 5. Structures of the promoters of MUC2, MUC5AC and MUC5B 5.1. Structure of the promoter of MUC2 5.2. Structure of the promoter of MUC5AC 5.3. Structure of the promoter of MUC5B 6. Transcriptional regulation of 11p15 mucin genes by exogenous factors 6.1. Transcriptional regulation of MUC2 6.1.1. Regulation in colon cancer cells 6.1.2. Regulation in lung cancer cells 6.2. Transcriptional regulation of MUC5AC 6.2.1. Regulation by inflammatory mediators 6.2.2. Regulation via EGF-receptor (EGF-R) signaling 6.3. Transcriptional regulation of MUC5B 6.3.1. Regulation of the promoter 6.3.2. Roles of intron 1 and intron 36 in MUC5B regulation 6.4. 11p15 mucin gene regulation during mucous cell differentiation 6.5. 11p15 mucin gene regulation by glucocorticoids and hormones 7. Transcriptional regulation of 11p15 mucin genes by the Sp-family of transcription factors 8. Repression of 11p15 mucin genes by methylation. Consequences during early development and tumorigenesis 9. Perspective 10. Acknowledgments 11. References
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