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Article Dans Une Revue Brain - A Journal of Neurology Année : 2015

Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate

Elise Météteau
  • Fonction : Auteur
Bénédicte Ballanger
Frédéric Bonnefoi
  • Fonction : Auteur
Stéphane Thobois
  • Fonction : Auteur
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Léon Tremblay
Véronique Sgambato-Faure

Résumé

Serotonergic (5-HT) neurons degenerate in Parkinson's disease. To determine the role of this 5-HT injury-besides the dopaminergic one in the parkinsonian symptomatology-we developed a new monkey model exhibiting a double dopaminergic/ serotonergic lesion by sequentially using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 3,4-methylenedioxy-N-methamphetamine (MDMA, better known as ecstasy). By positron emission tomography imaging and immunohistochemistry, we demonstrated that MDMA injured 5-HT nerve terminals in the brain of MPTP monkeys. Unexpectedly, this injury had no impact on tremor or on bradykinesia, but altered rigidity. It abolished the L-DOPA-induced dyskinesia and neuropsychiatric-like behaviours, without altering the anti-parkinsonian response. These data demonstrate that 5-HT fibres play a critical role in the expression of both motor and non-motor symptoms in Parkinson's disease, and highlight that an imbalance between the 5-HT and dopaminergic innervating systems is involved in specific basal ganglia territories for different symptoms.

Dates et versions

hal-02890769 , version 1 (17-07-2020)

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Maude Beaudoin-Gobert, Justine Epinat, Elise Météteau, Sandra Duperrier, Sara Neumane, et al.. Behavioural impact of a double dopaminergic and serotonergic lesion in the non-human primate. Brain - A Journal of Neurology , 2015, ⟨10.1093/brain/awv183⟩. ⟨hal-02890769⟩
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