Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuroscience Année : 2018

Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders.

Veronica Cartocci
  • Fonction : Auteur
Martina Catallo
  • Fonction : Auteur
Massimo Tempestilli
  • Fonction : Auteur
Marco Segatto
  • Fonction : Auteur
Maria Rosanna Bronzuoli
  • Fonction : Auteur
Caterina Scuderi
  • Fonction : Auteur
Michela Servadio
  • Fonction : Auteur
Viviana Trezza
  • Fonction : Auteur
Valentina Pallottini
  • Fonction : Auteur

Résumé

Autism spectrum disorders (ASDs) present a wide range of symptoms characterized by altered sociability, compromised communication and stereotypic/repetitive behaviors. These symptoms are caused by developmental changes, but the mechanisms remain largely unknown. Some lines of evidence suggest an impairment of the cholesterol/isoprenoid metabolism in the brain as a possible cause, but systematic analyses in rodent models of ASDs are lacking. Prenatal exposure to the antiepileptic drug valproate (VPA) is a risk factor for ASDs in humans and generates a well-established model for the disease in rodents. Here, we studied cholesterol/isoprenoid metabolism in different brain areas of infant, adolescent and adult rats prenatally exposed to VPA. VPA-treated rats present autistic-like symptoms, they show changes in cholesterol/isoprenoid homeostasis in some brain areas, a decreased number of oligodendrocytes and impaired myelination in the hippocampus. Together, our data suggest a relation between brain cholesterol/isoprenoid homeostasis and ASDs.

Dates et versions

hal-02884509 , version 1 (29-06-2020)

Identifiants

Citer

Veronica Cartocci, Martina Catallo, Massimo Tempestilli, Marco Segatto, Frank Pfrieger, et al.. Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders.. Neuroscience, 2018, 372, pp.27-37. ⟨10.1016/j.neuroscience.2017.12.053⟩. ⟨hal-02884509⟩

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