<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-02881536</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-14T21:27:24+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Identification of Ank G107 , a Muscle-specific Ankyrin-G Isoform</title>
            <author role="aut">
              <persName>
                <forename type="first">Claire</forename>
                <surname>Gagelin</surname>
              </persName>
              <idno type="halauthorid">1991528-0</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bruno</forename>
                <surname>Constantin</surname>
              </persName>
              <email type="md5">f282ad5dba7f63287c67a71fa4caf6da</email>
              <email type="domain">univ-poitiers.fr</email>
              <idno type="idhal" notation="string">bruno-constantin</idno>
              <idno type="idhal" notation="numeric">17628</idno>
              <idno type="halauthorid" notation="string">8940-17628</idno>
              <idno type="ORCID">https://orcid.org/0000-0003-1668-581X</idno>
              <idno type="IDREF">https://www.idref.fr/087251248</idno>
              <idno type="VIAF">https://viaf.org/viaf/210125629</idno>
              <affiliation ref="#struct-110187"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christiane</forename>
                <surname>Deprette</surname>
              </persName>
              <idno type="halauthorid">1991529-0</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Marie-Aline</forename>
                <surname>Ludosky</surname>
              </persName>
              <idno type="halauthorid">106295-0</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Michel</forename>
                <surname>Recouvreur</surname>
              </persName>
              <idno type="halauthorid">106296-0</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Jean</forename>
                <surname>Cartaud</surname>
              </persName>
              <email type="md5">76e4bfd8b1045f636e76b7b469a27801</email>
              <email type="domain">ijm.jussieu.fr</email>
              <idno type="idhal" notation="numeric">830375</idno>
              <idno type="halauthorid" notation="string">110451-830375</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Christian</forename>
                <surname>Cognard</surname>
              </persName>
              <email type="md5">06b33e509d4248b54eb4378b1a1f19f7</email>
              <email type="domain">univ-poitiers.fr</email>
              <idno type="idhal" notation="string">christian-cognard</idno>
              <idno type="idhal" notation="numeric">174761</idno>
              <idno type="halauthorid" notation="string">8803-174761</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-2412-9269</idno>
              <idno type="IDREF">https://www.idref.fr/10168911X</idno>
              <affiliation ref="#struct-110187"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Guy</forename>
                <surname>Raymond</surname>
              </persName>
              <idno type="halauthorid">396514-0</idno>
              <affiliation ref="#struct-110187"/>
            </author>
            <author role="crp">
              <persName>
                <forename type="first">Ekaterini</forename>
                <surname>Kordeli</surname>
              </persName>
              <email type="md5">61027fd626061324f36f8d066c4269de</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">ekaterini-kordeli</idno>
              <idno type="idhal" notation="numeric">830152</idno>
              <idno type="halauthorid" notation="string">106297-830152</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-5115-2202</idno>
              <affiliation ref="#struct-1131"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>Bruno</forename>
                <surname>Constantin</surname>
              </persName>
              <email type="md5">f282ad5dba7f63287c67a71fa4caf6da</email>
              <email type="domain">univ-poitiers.fr</email>
            </editor>
            <funder>This work was supported by the Centre National de la Recherche Scientifique, the Universités Paris 6 and 7, and by grants from the Association Française contre les Myopathies (to J. C. and G. R.). The costs of publication of this article were defrayed in part by the payment of page charges</funder>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2022-11-17 16:57:57</date>
              <date type="whenModified">2024-06-16 17:48:03</date>
              <date type="whenReleased">2022-11-17 18:36:55</date>
              <date type="whenProduced">2002-04-05</date>
              <date type="whenEndEmbargoed">2022-11-17</date>
              <ref type="file" target="https://hal.science/hal-02881536v1/document">
                <date notBefore="2022-11-17"/>
              </ref>
              <ref type="file" subtype="author" n="1" target="https://hal.science/hal-02881536v1/file/Gagelin-2002.pdf" id="file-3858404-3374387">
                <date notBefore="2022-11-17"/>
              </ref>
              <ref type="externalLink" target="http://www.jbc.org/content/277/15/12978.full.pdf"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="564042">
                <persName>
                  <forename>Bruno</forename>
                  <surname>Constantin</surname>
                </persName>
                <email type="md5">f282ad5dba7f63287c67a71fa4caf6da</email>
                <email type="domain">univ-poitiers.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-02881536</idno>
            <idno type="halUri">https://hal.science/hal-02881536</idno>
            <idno type="halBibtex">gagelin:hal-02881536</idno>
            <idno type="halRefHtml">&lt;i&gt;Journal of Biological Chemistry&lt;/i&gt;, 2002, 277 (15), pp.12978-12987. &lt;a target="_blank" href="https://dx.doi.org/10.1074/jbc.M111299200"&gt;&amp;#x27E8;10.1074/jbc.M111299200&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Journal of Biological Chemistry, 2002, 277 (15), pp.12978-12987. &amp;#x27E8;10.1074/jbc.M111299200&amp;#x27E9;</idno>
            <availability status="restricted">
              <licence target="https://creativecommons.org/licenses/by/4.0/">CC BY 4.0 - Attribution<ref corresp="#file-3858404-3374387"/></licence>
            </availability>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="UNIV-PARIS7" corresp="UNIV-PARIS">Université Denis Diderot - Paris VII</idno>
            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-POITIERS">Université de Poitiers</idno>
            <idno type="stamp" n="IJM">Institut Jacques Monod</idno>
            <idno type="stamp" n="UNIV-PARIS">Université Paris Cité</idno>
            <idno type="stamp" n="UP-SCIENCES">Université Paris Cité - Faculté des Sciences</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Identification of Ank G107 , a Muscle-specific Ankyrin-G Isoform</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Claire</forename>
                    <surname>Gagelin</surname>
                  </persName>
                  <idno type="halauthorid">1991528-0</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bruno</forename>
                    <surname>Constantin</surname>
                  </persName>
                  <email type="md5">f282ad5dba7f63287c67a71fa4caf6da</email>
                  <email type="domain">univ-poitiers.fr</email>
                  <idno type="idhal" notation="string">bruno-constantin</idno>
                  <idno type="idhal" notation="numeric">17628</idno>
                  <idno type="halauthorid" notation="string">8940-17628</idno>
                  <idno type="ORCID">https://orcid.org/0000-0003-1668-581X</idno>
                  <idno type="IDREF">https://www.idref.fr/087251248</idno>
                  <idno type="VIAF">https://viaf.org/viaf/210125629</idno>
                  <affiliation ref="#struct-110187"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christiane</forename>
                    <surname>Deprette</surname>
                  </persName>
                  <idno type="halauthorid">1991529-0</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Marie-Aline</forename>
                    <surname>Ludosky</surname>
                  </persName>
                  <idno type="halauthorid">106295-0</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Michel</forename>
                    <surname>Recouvreur</surname>
                  </persName>
                  <idno type="halauthorid">106296-0</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Jean</forename>
                    <surname>Cartaud</surname>
                  </persName>
                  <email type="md5">76e4bfd8b1045f636e76b7b469a27801</email>
                  <email type="domain">ijm.jussieu.fr</email>
                  <idno type="idhal" notation="numeric">830375</idno>
                  <idno type="halauthorid" notation="string">110451-830375</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Christian</forename>
                    <surname>Cognard</surname>
                  </persName>
                  <email type="md5">06b33e509d4248b54eb4378b1a1f19f7</email>
                  <email type="domain">univ-poitiers.fr</email>
                  <idno type="idhal" notation="string">christian-cognard</idno>
                  <idno type="idhal" notation="numeric">174761</idno>
                  <idno type="halauthorid" notation="string">8803-174761</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-2412-9269</idno>
                  <idno type="IDREF">https://www.idref.fr/10168911X</idno>
                  <affiliation ref="#struct-110187"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Guy</forename>
                    <surname>Raymond</surname>
                  </persName>
                  <idno type="halauthorid">396514-0</idno>
                  <affiliation ref="#struct-110187"/>
                </author>
                <author role="crp">
                  <persName>
                    <forename type="first">Ekaterini</forename>
                    <surname>Kordeli</surname>
                  </persName>
                  <email type="md5">61027fd626061324f36f8d066c4269de</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">ekaterini-kordeli</idno>
                  <idno type="idhal" notation="numeric">830152</idno>
                  <idno type="halauthorid" notation="string">106297-830152</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-5115-2202</idno>
                  <affiliation ref="#struct-1131"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">5882</idno>
                <idno type="issn">0021-9258</idno>
                <idno type="eissn">1083-351X</idno>
                <title level="j">Journal of Biological Chemistry</title>
                <imprint>
                  <publisher>American Society for Biochemistry and Molecular Biology</publisher>
                  <biblScope unit="volume">277</biblScope>
                  <biblScope unit="issue">15</biblScope>
                  <biblScope unit="pp">12978-12987</biblScope>
                  <date type="datePub">2002-04-05</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1074/jbc.M111299200</idno>
              <idno type="pubmed">11796721</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halDomain" n="sdv.bbm.bs">Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM]</classCode>
              <classCode scheme="halDomain" n="sdv.bc.bc">Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]</classCode>
              <classCode scheme="halDomain" n="sdv.bdd">Life Sciences [q-bio]/Development Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>We previously showed that alternatively spliced ankyrins-G, the Ank3 gene products, are expressed in skeletal muscle and localize to the postsynaptic folds and to the sarcoplasmic reticulum. Here we report the molecular cloning, tissue expression, and subcellular targeting of Ank(G107), a novel ankyrin-G from rat skeletal muscle. Ank(G107) lacks the entire ANK repeat domain and contains a 76-residue sequence near the COOH terminus. This sequence shares homology with COOH-terminal sequences of ankyrins-R and ankyrins-B, including the muscle-specific skAnk1. Despite widespread tissue expression of Ank3, the 76-residue sequence is predominantly detected in transcripts of skeletal muscle and heart, including both major 8- and 5.6-kb mRNAs of skeletal muscle. In 15-day-old rat skeletal muscle, antibodies against the 76-residue sequence localized to the sarcolemma and to the postsynaptic membrane and cross-reacted with three endogenous ankyrins-G, including one 130-kDa polypeptide that comigrated with in vitro translated Ank(G107). In adult muscle, these polypeptides appeared significantly decreased, and immunofluorescence labeling was no more detectable. Green fluorescent protein-tagged Ank(G107) transfected in primary cultures of rat myotubes was targeted to the plasma membrane. Deletion of the 76-residue insert resulted in additional cytoplasmic labeling suggestive of a reduced stability of Ank(G107) at the membrane. Recruitment of the COOH-terminal domain to the membrane was much less efficient but still possible only in the presence of the 76-residue insert. We conclude that the 76-residue sequence contributes to the localization and is essential to the stabilization of Ank(G107) at the membrane. These results suggest that tissue-dependent and developmentally regulated alternative processing of ankyrins generates isoforms with distinct sequences, potentially involved in specific protein-protein interactions during differentiation of the sarcolemma and, in particular, of the postsynaptic membrane.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="laboratory" xml:id="struct-1131" status="OLD">
          <idno type="IdRef">026536412</idno>
          <idno type="RNSR">199712638E</idno>
          <orgName>Institut Jacques Monod</orgName>
          <orgName type="acronym">IJM (UMR_7592)</orgName>
          <date type="start">2009-01-01</date>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>Université Paris Diderot, Bât. Buffon, 15 rue Hélène Brion, 75205 Paris cédex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.ijm.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMR_7592" active="#struct-300301" type="direct"/>
            <relation name="UMR7592" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-110187" status="OLD">
          <idno type="RNSR">197812342R</idno>
          <orgName>Laboratoire des biomembranes et de signalisation cellulaire [UMR 6558]</orgName>
          <orgName type="acronym">LBSC [Poitiers]</orgName>
          <date type="start">1978-01-01</date>
          <date type="end">2003-12-31</date>
          <desc>
            <address>
              <addrLine>40 avenue du Recteur Pineau – 86000 Poitiers – France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation name="UMR 6558" active="#struct-54493" type="direct"/>
            <relation name="UMR6558" active="#struct-441569" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300301" status="OLD">
          <idno type="IdRef">027542084</idno>
          <idno type="ISNI">0000000121514068</idno>
          <idno type="ROR">https://ror.org/02n7qrg46</idno>
          <orgName>Université Paris Diderot - Paris 7</orgName>
          <orgName type="acronym">UPD7</orgName>
          <date type="end">2019-12-31</date>
          <desc>
            <address>
              <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-paris-diderot.fr</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-441569" status="VALID">
          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <idno type="ROR">https://ror.org/02feahw73</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.cnrs.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-54493" status="VALID">
          <idno type="IdRef">026403765</idno>
          <idno type="ISNI">0000000121606368</idno>
          <idno type="ROR">https://ror.org/04xhy8q59</idno>
          <idno type="Wikidata">Q661056</idno>
          <orgName>Université de Poitiers =  University of Poitiers</orgName>
          <orgName type="acronym">UP</orgName>
          <desc>
            <address>
              <addrLine>15, rue de l'Hôtel Dieu - 86034 Poitiers Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-poitiers.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>