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Article Dans Une Revue Journal of Physiology - Paris Année : 2006

Synaptic plasticity, astrocytes and morphological homeostasis.

Michal Slezak
  • Fonction : Auteur
Zbigniew Soltys
  • Fonction : Auteur

Résumé

Recent discoveries suggest that astrocytes are an integral part of synaptic connections, as they sense and modulate synaptic activity. Moreover, there is evidence that astrocytes change the number of synaptic connections directly via synaptogenic signals or indirectly, by modifying the morphology of axons and dendrites. Here, we formulate the hypothesis that astrocytes mediate the morphological homeostasis of nerve cells, which is any adaptation of the morphology of a neuron to preserve its ability to respond to and generate synaptic activity during learning and memory-induced changes. We argue that astrocytes control neuronal morphology locally and across long-ranging assemblies of neurons and that on the other hand, astrocytes are part of the engram with plasticity-related changes affecting their morphology.

Dates et versions

hal-02878193 , version 1 (22-06-2020)

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Michal Slezak, Frank Pfrieger, Zbigniew Soltys. Synaptic plasticity, astrocytes and morphological homeostasis.. Journal of Physiology - Paris, 2006, 99 (2-3), pp.84-91. ⟨10.1016/j.jphysparis.2005.12.082⟩. ⟨hal-02878193⟩

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