Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles
Environmental science
Résumé
The impact on human health of long-term exposure to low doses of silver nanoparticles (AgNPs) remains
understudied. Cellular studies have shown the intracellular dissolution of AgNPs within endolysosomes
followed by Ag(I) binding to biomolecular thiolate-containing molecules. However, the precise subcellular
distribution of Ag(I) and the nature of the disrupted physiological pathways remained unknown. Novel
imaging approaches enabled us to visualize the trafficking of AgNP-containing lysosomes towards a
perinuclear location and a nuclear transfer of Ag(I) species with accumulation in the nucleoli. These Ag(I)
species impaired nuclear receptor activity, disrupting critical mechanisms of liver physiology in low dose
exposure scenarios, thus justifying further research into defining a framework for the safe use of AgNPs.
Origine : Fichiers produits par l'(les) auteur(s)
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