Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Environmental science‎.Nano Année : 2020

Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles

Environmental science

Isabelle Michaud-Soret
Remi Tucoulou
  • Fonction : Auteur
Pierre-Henri Jouneau
Aurélien Deniaud
Connectez-vous pour contacter l'auteur

Résumé

The impact on human health of long-term exposure to low doses of silver nanoparticles (AgNPs) remains understudied. Cellular studies have shown the intracellular dissolution of AgNPs within endolysosomes followed by Ag(I) binding to biomolecular thiolate-containing molecules. However, the precise subcellular distribution of Ag(I) and the nature of the disrupted physiological pathways remained unknown. Novel imaging approaches enabled us to visualize the trafficking of AgNP-containing lysosomes towards a perinuclear location and a nuclear transfer of Ag(I) species with accumulation in the nucleoli. These Ag(I) species impaired nuclear receptor activity, disrupting critical mechanisms of liver physiology in low dose exposure scenarios, thus justifying further research into defining a framework for the safe use of AgNPs.
Fichier principal
Vignette du fichier
Tardillo-Suarez et al HAL EnvtSciNano2020.pdf (1.83 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02873880 , version 1 (10-11-2020)

Identifiants

Citer

Vanessa Tardillo Suarez, Elizaveta Karepina, Mireille Chevallet, Benoit Gallet, Cécile Cottet-Rousselle, et al.. Nuclear translocation of silver ions and hepatocyte nuclear receptor impairment upon exposure to silver nanoparticles. Environmental science‎.Nano, 2020, 7 (5), pp.1373-1387. ⟨10.1039/c9en01348b⟩. ⟨hal-02873880⟩
153 Consultations
107 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More