In a context of decreasing resources and of climate change, lowering road vehicles consumption is a key point to meet CO2 reduction requirements. In addition to car technological advances, eco-driving is part of the solution but the road infrastructure should ensure its development. This work aims to demonstrate that road energy demand and associated pollutant emissions can be reduced by working out minor optimization of road infrastructure itself. For this to happen, a simple eco-driving potential criterion is built upon infrastructure parameters such as slopes and sight distances. This criterion aims to detect Misplaced Speed-sectioning Positions (MSP) with regard to the Starting Point of Deceleration (SPD); with speed-sectioning being the succession of speed changes along a given route. An enhanced energy waste formulation is then developed to quantify the vehicles energy waste due to misplaced road-signs. Thirdly, a traffic simulation constitutes a framework for energy evaluation; considering a full flow of vehicles, based on real traffic data, and by modeling several driver behaviors. Simulation results show that a significant fuel reduction of up to 5.5% can be achieved locally, simply by moving a road sign, for rural areas and without degrading road safety.