Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice - Archive ouverte HAL Accéder directement au contenu
Communication Dans Un Congrès Année : 2009

Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice

Résumé

Environmental pollutants such as benzo(a)pyrene (BaP) produce numerous deficits related to central deficiencies, including decreased motor activity, neuromuscular and autonomic abnormalities. While the carcinogenicity of BaP is well established, its neurotoxic effects have received less attention. Recently, some authors predicted the neurotoxic potential of polycyclic aromatic hydrocarbon particles deposited within the brain, and their subsequent adverse effects on development. Currently, the relationship between BaP, the cerebral metabolism of xenobiotics, and behaviour has received little attention. Therefore, we focused the present study on the effects of an oral subacute BaP administration (0.02, 0.2, 2, 20 and 200 mg/kg/day, 10 days) on the regional expression of CYP1A1 gene in the brain, and the anxiety-related behaviour in adult mice. The results showed that the subacute exposure to BaP induced significant increases in the CYP1A1 expression in the hippocampus, the frontal cortex, and the temporal cortex at the two highest doses administered (20 and 200 mg/kg) whereas the lowest BaP concentrations did not. At the same doses, the animals exhibited a reduction of their anxiety level, as reflected by significant increases in the time spent in the central part of the elevated plus maze correlated with reductions in the time spent in the closed arms. Concomitantly, significant increases in the number of head dipping were observed with the same animals in the hole board apparatus. The present study suggests that there is a dose-dependent relationship between the level of BaP exposure, the cerebral metabolism of this xenobiotic, and the modulation of anxiety-related behaviour.

Domaines

Toxicologie

Dates et versions

hal-02820358 , version 1 (06-06-2020)

Identifiants

Citer

Lei Cao, Nathalie Grova, Claude-P Muller, Henry Schroeder. Effects of an oral subacute administration of benzo(a)pyrene on cerebral CYP1A1 expression and anxiety-related behaviour in adult mice. 45. Congress of the European Societies of Toxicology, Oct 2008, Rhodes, Greece. ⟨10.1016/j.toxlet.2008.06.673⟩. ⟨hal-02820358⟩
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