Combustion instabilities depend on a variety of parameters and operating conditions. It is known, especially in the field of liquid rocket propulsion, that the pressure loss of an injector has an effect on its dynamics and on the coupling between the combustion chamber and the fuel manifold. However, its influence is not well documented in the technical literature dealing with gas turbine combustion dynamics. Effects of changes in this key design parameter are investigated in the present article by testing different swirlers at constant thermal power on a broad range of injection velocities in a well controlled laboratory scale single injector swirled combustor using liquid fuel. The objective is to study the impact of injection pressure losses on the occurrence and level of combustion instabilities by making use of a set of injectors having nearly the same outlet velocity profiles, the same swirl number and that establish flames that are essentially identical in shape. It is found that combustion oscillations appear on a wider range of operating conditions for injectors with the highest pressure loss, but that the pressure fluctuations caused by thermoacoustic oscillations are greatest when the injector head loss is low. Four types of instabilities coupled by two modes may be distinguished: the first group features a lower frequency, arises when the injector pressure loss is low and corresponds to a weakly coupled chamber-plenum mode. The second group appears in the form of a constant amplitude limit cycle, or as bursts at a slightly higher frequency and is coupled by a chamber mode. Spontaneous switching between these two types of instabilities is also observed in a narrow domain.