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Article Dans Une Revue BMC Infectious Diseases Année : 2019

Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis

Résumé

Background: We report hereby a severe case of Hantavirus Pulmonary Syndrome” (HPS) induced by Maripa virus in French Guiana and describe the mechanism of severity of the human disease. Case presentation: A 47-year- old patient started presenting a prodromic period with fever, dyspnea, cough and head ache. This clinical presentation was followed by a rapid respiratory, hemodynamic and renal failure leading to admission in the ICU. Biological exams revealed an increased haematocrit level with a paradoxical low protein level. Echocardiographic and hemodynamic monitoring showed a normal left ventricular function with low filling pressures, an elevated extravascular lung water index and pulmonary vascular permeability index. These findings were compatible with a capillary leak-syndrome (CLS). Conclusions: The severity of HPS caused by the virus Maripa in French Guiana can be explained by the tropism of hantavirus for the microvascular endothelial cell leading to a CLS.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

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hal-02735354 , version 1 (17-04-2024)

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Hatem Kallel, Severine Matheus, Claire Mayence, Stéphanie Houcke, Cyrille Mathien, et al.. Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis. BMC Infectious Diseases, 2019, 19 (1), pp.260. ⟨10.1186/s12879-019-3887-5⟩. ⟨hal-02735354⟩

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