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Communication Dans Un Congrès Année : 2019

Genomic and pedigree methods to analyse inbreeding depression in Basco-Bearnaise rams

Résumé

Inbreeding depression is caused by increased homozygosity of individuals and it is involved in the decrease of performance and fitness of the animals. The goal of this study is to estimate inbreeding depression for semen traits in Basco-Béarnaise rams. Genomic (e.g. using SNP-by-SNP approach) or pedigree-based inbreeding can be used to obtain inbreeding coefficients (f). It is possible to detect inbreeding depression (b) from the regression of the phenotype (y) on f, as y=Xβ+fb+u+e, where u is the vector of breeding values. In sheep, inbreeding from pedigree tends to be underestimated due to missing pedigrees. Inbreeding coefficients, f, were estimated using four methods. The first method used the traditional pedigree-based inbreeding. The second used pedigree-based inbreeding but accounting for non-zero relationships for unknown parents. The third method used the metafounder relationships in pedigree-based inbreeding. The fourth method calculates inbreeding from a combined relationship matrix using pedigree and genotypes with metafounder relationships. Breeding values, u, for the first three methods were estimated with the classical BLUP using phenotypes and pedigree information and the fourth method was Single Step GBLUP with metafounders.

Domaines

Autre [q-bio.OT]
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Dates et versions

hal-02734412 , version 1 (02-06-2020)

Identifiants

  • HAL Id : hal-02734412 , version 1
  • PRODINRA : 484668

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Zulma Vitezica, Ignacio Aguilar, Jean-Michel Astruc, Andres Legarra. Genomic and pedigree methods to analyse inbreeding depression in Basco-Bearnaise rams. 70. Annual Meeting of the European Federation of Animal Science (EAAP), Aug 2019, Ghent, Belgium. 717 p. ⟨hal-02734412⟩
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