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Article Dans Une Revue Applied and Environmental Microbiology Année : 2005

Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains

Résumé

Numerous industrial bacteria generate hydrogen peroxide (H(2)O(2)), which may inhibit the growth of other bacteria in mixed ecosystems. We isolated spontaneous oxidative-stress-resistant (SpOx) Lactococcus lactis mutants by using a natural selection method with milk-adapted strains on dairy culture medium containing H(2)O(2). Three SpOx mutants displayed greater H(2)O(2) resistance. One of them, SpOx3, demonstrated better behavior in different oxidative-stress situations: (i) higher long-term survival upon aeration in LM17 and milk and (ii) the ability to grow with H(2)O(2)-producing Lactobacillus delbrueckii subsp. delbrueckii strains. Furthermore, the transit kinetics of the SpOx3 mutant in the digestive tract of a human flora-associated mouse model was not affected.

Dates et versions

hal-02681903 , version 1 (01-06-2020)

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Citer

Tatiana Rochat, Jean-Jacques J.-J. Gratadoux, Gerard G. Corthier, Bernard Coqueran, Maria-Elena Nader-Macias, et al.. Lactococcus lactis SpOx spontaneous mutants: a family of oxidative-stress-resistant dairy strains. Applied and Environmental Microbiology, 2005, 71 (5), pp.2782-2788. ⟨10.1128/AEM.71.5.2782-2788.2005⟩. ⟨hal-02681903⟩

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