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Article Dans Une Revue International Journal of Biochemistry and Cell Biology Année : 2005

Lysosomal proteolysis in skeletal muscle

Résumé

Lysosomal proteases are abundantly expressed in fetal muscles, but poorly represented in the adult skeletal muscles. The lysosomal proteolytic system is nonetheless stimulated in adult muscles in a variety of pathological conditions. Furthermore, recent investigations describe autophagosomes in muscle fibers in vitro and in vivo, and report myopathies with excessive autophagy. This review presents our current knowledge about the lysosomal proteolytic system and summarizes the evidences pertaining to the role of lysosomes and autophagosomes in muscle physiology and pathology.

Dates et versions

hal-02681176 , version 1 (31-05-2020)

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Citer

Daniel D. Bechet, Amina Tassa, Daniel Taillandier, Lydie Combaret, Didier Attaix. Lysosomal proteolysis in skeletal muscle. International Journal of Biochemistry and Cell Biology, 2005, 37 (10), pp.2098-2114. ⟨10.1016/j.biocel.2005.02.029⟩. ⟨hal-02681176⟩

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