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Article Dans Une Revue Journal of General Virology Année : 2002

Lymphoid activation : a confounding factor in AIDS vaccine development ?

Résumé

In a previous vaccination trial, inoculation of env gene DNA failed to elicit a detectable antibody response, yet accelerated virus dissemination in most immunized cats following challenge with feline immunodeficiency virus. This result raised the possibility that cell-mediated immune responses had given rise to immune-mediated enhancement of infection. Since high-level replication of immunodeficiency viruses in lymphocytes requires cellular activation, antigen-specific responses or non-specific polyclonal activation may have increased the frequency of optimal target cells. In the present DNA vaccination trial, although designed so as to minimize non-specific polyclonal activation, immune-mediated enhancement was nonetheless observed in certain immunized cats. Moreover, rapid virus dissemination in vivo was associated with the presence of T-helper responses prior to challenge, and was linked to increased susceptibility of lymphocytes to ex vivo infection. Immune activation may thus be a confounding factor in vaccination against lentivirus infection, diminishing vaccine efficacy and giving rise to immune-mediated enhancement.

Domaines

Immunologie
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Dates et versions

hal-02676041 , version 1 (31-05-2020)

Identifiants

  • HAL Id : hal-02676041 , version 1
  • PRODINRA : 167231

Citer

Jennifer Richardson, Sophie Broche, Sandrine Baud, Thiérry Leste Lasserre, Françoise Féménia, et al.. Lymphoid activation : a confounding factor in AIDS vaccine development ?. Journal of General Virology, 2002, 83 (10), pp.2515-2521. ⟨hal-02676041⟩
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