Bacterial polyesters grafted with poly(ethylene glycol) : behaviour in aqueous media
Résumé
An easy method for grafting of poly(3-hydroxyoctanoate-co-3-hydroxyundecenoate) (PHOU) was developed. Oxidation of the pendant double bonds of PHOU into carboxyl groups to yield poly(3-hydroxyoctanoate-co-3-hydroxy-9-carboxydecanoate) (PHOD) and the esterification of the carboxyl side groups with poly(ethylene glycol) (PEG) were carried out in a single reaction solution. The grafting yield is dependent on the molar mass of the PEG graft. The maximum carboxyl group conversion (52%) was obtained with PEG M-n = 350 and decreased with increasing molar mass of PEG (19% for PEG M-n = 2000). Yields were determined by H-1 and C-13 NMR. Short PEG grafts lowered the glass transition temperature (PHOD-g-PEG 350 -57 degrees C) compared to PHOD (-19 degrees C) and PHOU (-39 degrees C). This effect depends on the COOH conversion and PEG chain length. Grafting enhanced the hydrophilic character of the modified polymers making them soluble in polar solvents, such as alcohols and water/acetone mixtures. PHOD-g-PEG films were more stable towards hydrolytic degradation as PHOD films. No obvious modification of films was observed after more than 200 days at pH 7.2 and 37 degrees C. The molar mass of the grafted polymers decreased only slightly during this period, while PHOD films were hydrolyzed into soluble fragments.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)