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Article Dans Une Revue PLoS Biology Année : 2008

A mechanism regulating the onset of Sox2 expression in the embryonic neural plate

Résumé

During early development, when the embryo has three layers of cells (ectoderm, mesoderm, and endoderm), a region of the ectoderm called the neural plate becomes specified to generate the entire nervous system. One of the earliest molecular markers for the neural plate is the transcription factor Sox2, which is critical for cells to acquire their neural fates and also defines neural progenitor character. We know very little about the intracellular mechanisms by which the neural plate cells acquire these fates. Here, we show that recruitment of transcriptional repressors to chromatin-remodeling complexes regulate the onset of Sox2 expression. Competitive interactions between three proteins, ERNI, BERT, and Geminin, modulate the choice of repressors and regulate Sox2 expression. During gastrulation, when the three embryonic cell layers form, ERNI recruits the repressor HP1γ to prevent Geminin from activating Sox2 prematurely. By the end of gastrulation, this repression is counteracted by competitive binding of BERT to ERNI and Geminin, causing activation of Sox2. We propose that this mechanism regulates the timing of Sox2 activation in the very early neural plate and thus helps to define the domain that will give rise to the nervous system.
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Dates et versions

hal-02662617 , version 1 (31-05-2020)

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Costis Papanayotou, Anne Mey, Anne-Marie Birot, Yasushi Saka, Sharon Boast, et al.. A mechanism regulating the onset of Sox2 expression in the embryonic neural plate. PLoS Biology, 2008, 6 (1), pp.109-123. ⟨10.1371/journal.pbio.0060002⟩. ⟨hal-02662617⟩
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