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Article Dans Une Revue Archives of Biochemistry and Biophysics Année : 2007

Magnesium and neoplasia : From carcinogenesis to tumor growth and progression or treatment

Résumé

Magnesium is involved in a wide range of biochemical reactions that are crucial to cell proliferation, differentiation, angiogenesis, and apoptosis. Changes in magnesium availability have been shown to influence biological responses of immuno-inflammatory cells. Equally plausible seems to be an involvement of magnesium in the multistep and interconnected processes that lead to tumor formation and development; however, the "how" and "when" of such an involvement remain to be defined. Here, we reviewed in vitro and in vivo data that indicated a role for magnesium in many biological and clinical aspects of cancer (from neoplastic transformation to tumor growth and progression or pharmacologic treatment). In adopting this approach we went through a full circle from molecular aspects to observational or epidemiological studies that could reconcile in a unifying picture the otherwise fragmentary or puzzling data currently available on the role of magnesium in cancer.

Dates et versions

hal-02661148 , version 1 (30-05-2020)

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Federica Wolf, Jeanette Maier, Anna Nasulewicz, Christine Feillet Coudray, Matteo Simonacci, et al.. Magnesium and neoplasia : From carcinogenesis to tumor growth and progression or treatment. Archives of Biochemistry and Biophysics, 2007, 458 (1), pp.24-32. ⟨10.1016/j.abb.2006.02.016⟩. ⟨hal-02661148⟩
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