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Article Dans Une Revue Journal of Virology Année : 2013

NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon

Virginie Doceul
Estelle Lara
  • Fonction : Auteur
Emmanuel Breard
Pierre-Olivier Vidalain
Stéphanie Dabo
Stéphan Zientara
Damien Vitour
  • Fonction : Auteur

Résumé

Upon infection with Bluetongue virus (BTV), an arthropod-borne virus, type I interferon (IFN-I) is produced in vivo and in vitro. IFN-I is essential for the establishment of an antiviral cellular response, and most if not all viruses have elaborated strategies to counteract its action. In this study, we assessed the ability of BTV to interfere with IFN-I synthesis and identified the nonstructural viral protein NS3 as an antagonist of the IFN-I system.

Dates et versions

hal-02648742 , version 1 (29-05-2020)

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Citer

Emilie Chauveau, Virginie Doceul, Estelle Lara, Emmanuel Breard, Corinne Sailleau, et al.. NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon. Journal of Virology, 2013, 87 (14), pp.8241 - 8246. ⟨10.1128/JVI.00678-13⟩. ⟨hal-02648742⟩
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