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            <title xml:lang="en">Is the assessment of mixture toxicity an impossible challenge?</title>
            <title xml:lang="fr">L’évaluation de la toxicité des mélanges est-elle un défi impossible ?</title>
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                <term xml:lang="en">environmental and occupational health</term>
                <term xml:lang="en">Assessment of toxic risks</term>
                <term xml:lang="fr">Chemicals</term>
                <term xml:lang="fr">Mixture</term>
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              <p>In their environment, living organisms are frequently exposed to multiple toxic chemicals acting at the same time. This article gives an overview of the main methods available to assess risks in the case of combined exposure to several chemicals acting together. Some basic ideas and terminology are briefly recalled specifying the main concepts in use. Current tools and methods to assess risks related to mixture toxicity are then reviewed together with the prospects opened by ongoing research.</p>
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              <p>Dans leur environnement usuel, les organismes vivants sont fréquemment exposés à de multiples substances toxiques agissant de manière concomitante. Cet article donne un aperçu des principales méthodes disponibles pour évaluer les risques liés à l’exposition combinée à plusieurs substances chimiques. Quelques notions de base sont brièvement rappelées en précisant la terminologie et en décrivant les principaux concepts en usage. Les outils et méthodes actuellement utilisés pour évaluer les risques liés aux substances en coexposition sont ensuite passés en revue ainsi que les perspectives ouvertes par les recherches en cours.</p>
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