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                <term xml:lang="en">hypoxemia</term>
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              <p>This study investigated the sources of physiological stress in diving by comparing SCUBA dives (stressors: hydrostatic pressure, cold, and hyperoxia), apneic dives (hydrostatic pressure, cold, physical activity, hypoxia), and dry static apnea (hypoxia only). We hypothesized that despite the hypoxia induces by a long static apnea, it would be less stressful than SCUBA dive or apneic dives since the latter combined high pressure, physical activity, and cold exposure. Blood samples were collected from 12SCUBA and 12 apnea divers before and after dives. On a different occasion, samples were collected from the apneic group before and after a maximal static dry apnea. We measured changes in levels of the stress hormones cortisol and copeptin in each situation. To identify localized effects of the stress, we measured levels of the cardiac injury markers troponin (cTnI) and brain natriuretic peptide (BNP), the muscular stress markers myoglobin and lactate), and the hypoxemia marker ischemia-modified albumin (IMA). Copeptin, cortisol, and IMA levels increased for the apneic dive and the static dry apnea, whereas they decreased for the SCUBA dive. Troponin, BNP, and myoglobin levels increased for the apneic dive, but were unchanged for the SCUBA dive and the static dry apnea. We conclude that hypoxia induced by apnea is the dominant trigger for the release of stress hormones and cardiac injury markers, whereas cold or and hyperbaric exposures play a minor role. These results indicate that subjects should be screened carefully for pre-existing cardiac diseases before undertaking significant apneic maneuvers.</p>
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              <addrLine>Direction générale AP-HM80, rue Brochier13 354 Marseille Cedex 5</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301315" status="VALID">
          <idno type="ISNI">0000 0001 0304 0719 </idno>
          <idno type="ROR">https://ror.org/029a4pp87</idno>
          <orgName>Hôpital Nord [CHU - APHM]</orgName>
          <date type="start">1964</date>
          <desc>
            <address>
              <addrLine>Hôpital Nord - Chemin des Bourrely13915Marseille cedex 20</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://fr.ap-hm.fr/nos-hopitaux/hopital-nord</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300092" status="VALID">
          <orgName>Service de Santé des Armées</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
            <ref type="url">https://www.defense.gouv.fr/sante</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303091" status="VALID">
          <idno type="IdRef">031122337</idno>
          <idno type="ROR">https://ror.org/02m9kbe37</idno>
          <orgName>Université de Toulon</orgName>
          <orgName type="acronym">UTLN</orgName>
          <desc>
            <address>
              <addrLine>Avenue de l'Université - BP 20132 - 83957 La Garde Cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-tln.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>