Cyperaceae species are potential sources of natural mammalian arginase inhibitors with positive effects on vascular function - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Natural Products Année : 2017

Cyperaceae species are potential sources of natural mammalian arginase inhibitors with positive effects on vascular function

Résumé

The inhibition of arginase is of substantial interest for the treatment of various diseases of public health interest including cardiovascular diseases. Using an ex vivo experiment on rat aortic rings and an in vitro assay with liver bovine purified arginase, it was demonstrated that several polyphenolic extracts from Cyperus and Carex species possess vasorelaxant properties and mammalian arginase inhibitory capacities. Phytochemical studies performed on these species led to the identification of eight compounds, including monomers, dimers, trimers, and tetramers of resveratrol. The potential of these stilbenes as inhibitors of mammalian arginase was assessed. Five compounds, scirpusin B (5), ε-viniferin (4), cyperusphenol B (6), carexinol A (7), and the new compound virgatanol (1), showed significant inhibition of arginase, with percentage inhibition ranging from 70% to 95% at 100 μg/mL and IC50 values between 12.2 and 182.1 μM, confirming that these stilbenes may be useful for the development of new pharmaceutical products.
Fichier non déposé

Dates et versions

hal-02620740 , version 1 (25-05-2020)

Identifiants

Citer

Kamel Arraki, Perle Totoson, Alain Decendit, Alain Badoc, Andy Zedet, et al.. Cyperaceae species are potential sources of natural mammalian arginase inhibitors with positive effects on vascular function. Journal of Natural Products, 2017, 80 (9), pp.2432-2438. ⟨10.1021/acs.jnatprod.7b00197⟩. ⟨hal-02620740⟩

Collections

INRA INRAE
16 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More