Trifluoromethyl Radical Triggered Radical Cyclization of N-Benzoyl Ynamides leading to Isoindolinones - Archive ouverte HAL Access content directly
Journal Articles Science China Chemistry Year : 2019

Trifluoromethyl Radical Triggered Radical Cyclization of N-Benzoyl Ynamides leading to Isoindolinones

Abstract

Under photocatalytic reductive conditions, trifluoromethyl radical addition onto an ynamide followed by cyclization on a benzoyl moiety produces diverse isoindolinone platforms with good yields. The selectivity of the radical cyclization, N-benzoyl vs. N-benzyl as radical acceptor and the E/Z ratio of isomers have been rationalized by modeling.

Domains

Catalysis
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Dates and versions

hal-02616094 , version 1 (24-05-2020)

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Maud Cassé, Christian Nisole, Héloïse Dossmann, Yves Gimbert, Jean-Marie Fourquez, et al.. Trifluoromethyl Radical Triggered Radical Cyclization of N-Benzoyl Ynamides leading to Isoindolinones. Science China Chemistry, 2019, 62, pp.1542-1546. ⟨10.1007/s11426-019-9627-x⟩. ⟨hal-02616094⟩
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