Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine - Archive ouverte HAL
Article Dans Une Revue Drug Discovery Today Biosilico Année : 2020

Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

Résumé

Aptamers are RNA or DNA oligonucleotides interacting to form unique 3D target conformations with high affinity and specificity, and are emerging as a powerful class of ligands for therapeutic applications. In addition, dendrimers are well-defined nano-sized symmetric polymeric molecules. In this review, we provide an analysis of the use of dendrimers modified with aptamers as nonviral vectors to specifically target tumor cells. Various anticancer agents have been encapsulated with dendrimers complexing with aptamers, including epirubicin, camptothecin, Bcl-xL short hairpin (sh)RNA, and 5-fluorouracil rhodamine-labeled dextran. Other types of polymeric nanoparticle (NP)–aptamer bioconjugates have also been developed and loaded with Pt(IV) derivatives, to target specific tumor cells.

Dates et versions

hal-02612719 , version 1 (19-05-2020)

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Citer

Serge Mignani, Xangyang Shi, Valentin Ceña, Jean Pierre Majoral. Dendrimer– and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: a new approach in medicine. Drug Discovery Today Biosilico, 2020, 25 (6), pp.1065-1073. ⟨10.1016/j.drudis.2020.03.009⟩. ⟨hal-02612719⟩
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