Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers - Archive ouverte HAL
Article Dans Une Revue Food and Chemical Toxicology Année : 2014

Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers

N. Sebastià
  • Fonction : Auteur
D. Hervás
  • Fonction : Auteur
Maria Almonacid
  • Fonction : Auteur
J.I. Villaescusa
  • Fonction : Auteur
J.M. Soriano
  • Fonction : Auteur
V. Sahuquillo
  • Fonction : Auteur
V. Esteban
  • Fonction : Auteur
G. Verdú
  • Fonction : Auteur
E. Such
  • Fonction : Auteur
A. Montoro
  • Fonction : Auteur

Résumé

According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers ( n= 48) and non-smokers ( n= 53), aged from 18 to 49. years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (≥10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. © 2014.

Dates et versions

hal-02611883 , version 1 (18-05-2020)

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Citer

N. Sebastià, D. Hervás, Maria Almonacid, J.I. Villaescusa, J.M. Soriano, et al.. Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers. Food and Chemical Toxicology, 2014, 66, pp.107-112. ⟨10.1016/j.fct.2014.01.011⟩. ⟨hal-02611883⟩

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