Effects of microbiota-directed foods in gnotobiotic animals and undernourished children - Archive ouverte HAL Access content directly
Journal Articles Science Year : 2019

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Abstract

To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
Fichier principal
Vignette du fichier
eaau4732.full.pdf (3.01 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02586781 , version 1 (15-05-2020)

Licence

Attribution

Identifiers

Cite

Jeanette L Gehrig, Siddarth Venkatesh, Hao-Wei Chang, Matthew C Hibberd, Vanderlene L Kung, et al.. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. Science, 2019, 365 (6449), ⟨10.1126/science.aau4732⟩. ⟨hal-02586781⟩
178 View
147 Download

Altmetric

Share

Gmail Facebook X LinkedIn More